Unraveling Mechanisms of Scarring Alopecia in Discoid Lupus: Insights from Spatial Transcriptomics
July 2024
in “
Journal of Investigative Dermatology
”
scarring alopecia Discoid Lupus Erythematosus DLE Spatial Transcriptomics CD8+ T cells epithelial hair follicle stem cells fibrosis hair loss Cellular response Extracellular matrix formation Keratinization Collagen formation perifollicular dermis Flow cytometry CD34 CD62L T cell regions CD34+ stem cells scarring hair loss lupus hair follicle stem cells skin fibrosis hair thinning cell response matrix formation skin keratin collagen skin dermis stem cell therapy
Studysummary CD8+ T cells attack hair follicle stem cells, causing scarring and hair loss in Discoid Lupus.
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