Comparative Spatial Transcriptomics of Hair Follicle-T Cell Interactions in Mouse, Dog, and Human Reveals Conserved Drivers of Primary Cicatricial Alopecia

This study used spatial transcriptomics to investigate T cell-hair follicle interactions in cutaneous lupus erythematosus across mice, dogs, and humans, finding that CXCR3+ T cells and B cells are enriched in lesional skin, with implications for potential therapeutic targets.

This research investigated immune cell involvement in various types of inflammatory alopecia by analyzing gene expression data from scalp samples, revealing distinct cellular changes in conditions like Alopecia Areata, Frontal Fibrosing Alopecia, Lichen Planopilaris, and Central Centrifugal Cicatricial Alopecia, which may inform future therapeutic targets.

In this study, single-cell sequencing revealed clonal expansions of CD4+ and CD8+ T cells in murine and human alopecia areata, supporting the development of predictive models for human disease.

This study developed a comprehensive atlas of human scalp tissue to uncover cell states and lineages in hair follicles, identifying disease-specific cellular changes associated with non-scarring and scarring hair loss, which may offer new diagnostic and therapeutic insights.

Alopecia areata involves complex immune cell interactions, especially between CD8+ T cells and macrophages, which could help develop new treatments.