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GlossaryS100A8

protein involved in immune response and inflammation

S100A8 is a protein that plays a role in the body's immune response and inflammation. It is part of the S100 family of proteins and is often found in high levels in conditions involving chronic inflammation, such as certain types of alopecia (hair loss) and other inflammatory diseases.

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Comparative Spatial Transcriptomics of Hair Follicle-T Cell Interactions in Mouse, Dog, and Human Reveals Conserved Drivers of Primary Cicatricial Alopecia

research Comparative Spatial Transcriptomics of Hair Follicle-T Cell Interactions in Mouse, Dog, and Human Reveals Conserved Drivers of Primary Cicatricial Alopecia

January 2025 in “bioRxiv (Cold Spring Harbor Laboratory)”

Potential therapeutic targets for scarring hair loss are identified.

research Significance of the S100A4 Protein in Psoriasis

45 citations, July 2009 in “Journal of Investigative Dermatology”

The S100A4 protein is more common in psoriatic skin and could be a target for treating psoriasis.

research What Does the Concept of the Stem Cell Niche Really Mean Today?

163 citations, March 2012 in “BMC biology”

Stem cell niches support, regulate, and coordinate stem cell functions.

research The Role of the Skin Microbiome in Wound Healing

January 2024 in “Burns and trauma”

The skin microbiome helps heal wounds and can be targeted to improve healing.

research Transcriptome Meta-Analysis Confirms the Hidradenitis Suppurativa Pathogenic Triad: Upregulated Inflammation, Altered Epithelial Organization, and Dysregulated Metabolic Signaling

13 citations, September 2022 in “Biomolecules”

The research confirms that Hidradenitis Suppurativa is characterized by increased inflammation, disrupted skin cell organization, and abnormal metabolic processes.

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