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GlossaryS100A8

protein involved in immune response and inflammation

S100A8 is a protein that plays a role in the body's immune response and inflammation. It is part of the S100 family of proteins and is often found in high levels in conditions involving chronic inflammation, such as certain types of alopecia (hair loss) and other inflammatory diseases.

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Research

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research 322 Upregulation of SERPINB3/B4 and S100A7-9 in hidradenitis suppurativa/acne inversa

September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

Certain proteins are significantly increased in the skin of people with hidradenitis suppurativa.

Comparative Spatial Transcriptomics of Hair Follicle-T Cell Interactions in Mouse, Dog, and Human Reveals Conserved Drivers of Primary Cicatricial Alopecia

research Comparative spatial transcriptomics of hair follicle-T cell interactions in mouse, dog and human reveals conserved drivers of primary cicatricial alopecia

January 2025 in “bioRxiv (Cold Spring Harbor Laboratory)”

Potential therapeutic targets for scarring hair loss are identified.

Molecular Profiling of Frontal Fibrosing Alopecia Reveals TH1 and JAK-STAT Up-Regulation with No Suppression of Hair Keratins

research 1322 Molecular profiling of frontal fibrosing alopecia (FFA) reveals TH1 and JAK-STAT up-regulation with no suppression of hair keratins

2 citations , April 2018 in “Journal of Investigative Dermatology”

Frontal fibrosing alopecia shows increased inflammation and JAK-STAT pathway activity without reduced hair proteins.

research A functional role of S100A4/non-muscle myosin IIA axis for pro-tumorigenic vascular functions in glioblastoma

9 citations , April 2022 in “Cell Communication and Signaling”

High S100A4 levels worsen glioblastoma by promoting blood vessel growth.

research A Functional Role of S100A4/Non-Muscle Myosin IIA Axis for Pro-Tumorigenic Vascular Functions in Glioblastoma

December 2021 in “Research Square (Research Square)”

S100A4 and NMIIA promote tumor growth in glioblastoma by enhancing blood vessel functions.

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Community Join

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community RU55481

4 upvotes 12 years ago

community mallia therapeutics 8T3 scd83 molecule for ffa/lpp mainly and aga

in Technology 8 upvotes 2 months ago

A user applied the 8T3 product for hair loss, targeting LPP and AGA, and plans to update on its effectiveness. The product uses a saline buffered phosphate vehicle, suitable for those intolerant to ethanolic vehicles.

community RU-58441 Janoshik test result of Made-In-China Supplier

in Product 26 upvotes 4 months ago

A user ordered RU58841 from a Chinese supplier, found it to be less than 99% pure, and plans to try a different seller next time. Concerns were raised about impurities, but the user believes they are likely inactive fillers rather than harmful substances.

community A warning to anyone considering 3rd party sourcing PP405 or its analogs

in Treatment 16 upvotes 2 days ago

Be cautious when sourcing PP405 or its analogs from third-party suppliers due to potential safety risks and lack of regulatory approval. The conversation highlights concerns about counterfeit products and the absence of reliable testing, making it risky to use such treatments.

community HMI 115 hasn't done phase one yet for AGA?

in Research/Science 5 upvotes 3 years ago

User asks if HMI 115 hasn't done phase 1 for AGA in humans. Conversation includes treatments Min, Fin, and RU.

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