Dendrobium Officinale Polysaccharide Promotes Angiogenesis, Follicle Regeneration, and Hair Growth Through Activation of the WNT Signaling Pathway

May 2024 in “ Regenerative Therapy ”

Yujin Zhang, Qing Tang, Bijun Zeng, WANG Fengjiao, Meijunzi Luo, Pan Huang, Ling Chen, Haizhen Wang

Dendrobium officinale polysaccharide DOP WNT signaling pathway hair growth follicle regeneration dermal papilla cells DPCs mouse vascular endothelial cells MVECs neovascularization β-catenin Cyclin D1 WNT pathway hair loss treatment

Studysummary This laboratory study found that dendrobium officinale polysaccharide (DOP) stimulated hair follicle and hair growth in mice by activating the WNT signaling pathway.

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The study demonstrates that Dendrobium officinale polysaccharide (DOP) promotes hair growth and follicle regeneration by activating the WNT signaling pathway. Using mouse models and cell cultures, DOP was found to enhance the biological functions of dermal papilla cells (DPCs) and mouse vascular endothelial cells (MVECs), leading to improved hair regeneration and neovascularization. Key proteins like β-catenin and Cyclin D1 were upregulated, and inhibiting the WNT pathway reversed DOP's beneficial effects, highlighting the pathway's critical role. The findings suggest DOP's potential as a therapeutic agent for treating hair loss.

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