The Role of DWAT-Immune Crosstalk in Hair Follicle Microenvironment in Hair Regeneration

This study reviewed evidence suggesting that the loss of dermal white adipose tissue (dWAT) during menopause may be linked to decreased estrogen levels, potentially affecting skin health, and discussed non-hormonal treatments, like magnolol, that might help restore dWAT and improve menopausal skin changes.

In this study, PDLLA treatment in middle-aged mice was observed to enhance hair growth by increasing macrophage M2 polarization and hair follicle stem cell proliferation, potentially rejuvenating the skin's microenvironment and offering a novel approach for age-related hair loss.

This study found that regulatory T cells accumulate in hair follicle epithelium via the Cxcr4-Cxcl12 axis, partially influenced by glucocorticoid receptor signaling, promoting hair regeneration; similar mechanisms were observed in human and murine skin.

This review discusses the roles of dermal white adipose tissue in skin functions and pathology, underscoring its antibacterial activity and potential anti-fibrotic role, but reports no new experimental results.

This study found that adipose-derived stem cells with DKK1 knocked out using CRISPR/Cas9 promoted hair growth in an alopecia areata model more effectively than untreated stem cells, suggesting DKK1 is a potential therapeutic target for this condition.

This study suggests that the ADIPOQ gene polymorphism may influence the risk of alopecia areata in Egyptians, with adiponectin levels potentially serving as a marker for hair loss severity.

This study highlights the potential of fat injections for treating alopecia, as they may promote hair regrowth, reduce inflammation, and exhibit limited adverse effects, suggesting efficacy and safety in managing the condition.

This study observed that in the bald scalps of male patients with androgenetic alopecia, there was a significant downregulation of the PPAR signaling pathway, suggesting reduced adipogenesis potentially influencing hair cycling processes.

This study found that feeding mice a high-fat diet with fish oil leads to hair loss through a mechanism involving omega-3 fatty acids and TNF-α signaling, with epidermal fatty acid binding protein playing a key role.

This study found that the secretory profiles of adipose-derived stem cells vary between balding and non-balding scalp areas in androgenetic alopecia patients, suggesting involvement of angiogenic and inflammatory processes in the condition's development.

Adiponectin reduces hair pigmentation and affects hair growth signals.

This study examined aging hair follicle stem cells in mice and found that inflammation reduction in dermal white adipose tissue can stimulate regenerative behavior, highlighting its role in hair follicle aging.

This study demonstrates that dermal white adipose tissue regulates human hair growth and pigmentation through hepatocyte growth factor secretion, highlighting potential therapeutic targets for hair-related disorders.

This review explores the current understanding of leptin's role in psoriasis and other skin diseases but reports no new clinical findings, emphasizing that the exact mechanisms of its impact are still being investigated.

This review discusses the role of the immune niche in hair follicle regeneration and its impact on different forms of alopecia, highlighting research gaps and potential therapeutic strategies.

This study found that mature dermal adipocytes have high plasticity, undergoing dedifferentiation and redifferentiation, which plays a significant role in hair cycling and wound healing.

This research indicates that KCED-1 and KCED-2 effectively induce adiponectin production in human subcutaneous fat, which may promote hair growth on the scalp.

This review discusses the role of perifollicular macrophages in hair growth and suggests targeting them could be relevant for managing hair growth disorders, but reports no new results.

This review discusses dermal white adipose tissue's roles in skin immunity, highlighting its antimicrobial function and interactions with other immune cells, but reports no new clinical results.

The authors concluded that dermal white adipose tissue, influenced by factors like light irradiation, plays a significant role in modulating hair follicle cycles and could be targeted for hair growth treatments.

This study reports that polyphenols from Annurca apples may safely promote hair growth and protect against chemotherapy-induced alopecia without interfering with chemotherapy regimens.

In this study, Alox15 knockout mice exhibited disrupted skin integrity and increased inflammation, suggesting that Alox15-mediated resolvin D2 production is crucial for maintaining skin homeostasis by suppressing inflammation.

In this study, adipose-derived stem cells from superficial adipose tissue showed higher regenerative potential, and more macrophages were found in superficial than deep adipose tissue, potentially influenced by skin microbiota.

This study found that transforming growth factor-β1 and CX3CR1 are crucial for recruiting specific macrophages essential for wound-induced hair growth in mice.

In this study, researchers found that eccrine sweat glands in human scalp skin are morphologically integrated into the pilosebaceous unit, suggesting they form a common homeostatic tissue environment with adjacent structures.

This review discusses the unique features of dermal white adipose tissue, its interaction with hair follicles, and its role in skin physiology, reporting no new experimental findings.

In this case study, a female patient with folliculitis decalvans experienced hair re-growth and relief from symptoms like pain and burning after undergoing autologous fat transplantation, suggesting beneficial effects from stem cell therapy assisted by the inflammatory action of transplanted fat.

This study found that skin-resident Treg cells regulate hair follicle stem cell proliferation and differentiation through the Jag1-Notch signaling pathway, influencing hair regeneration.

This study found that men with androgenetic alopecia had significantly higher plasma leptin levels, which were associated with an increased risk of developing the condition.

This review discusses the roles of dermal white adipose tissue (dWAT) as an insulator, antibiotic, and regenerative tissue, highlighting its importance in systemic metabolism and immune function, but reports no new clinical results.

Leptin helps start the growth phase of hair.

This study found that leptin acts as an inducer of the anagen phase in hair follicles, suggesting its role as a potential player in hair biology.

This review discusses the role of leptin in skin biology and pathology, highlighting its potential in enhancing skin regeneration, hair cycle progression, and wound healing, but reports no new clinical results.