Menopause and Dermal White Adipose Tissue Depletion: Mechanistic Links, Adipogenesis, and Regenerative Therapeutic Replacement

January 2026 in “ Journal of Cosmetic Dermatology ”

Alan D. Widgerow, Mary E. Ziegler, Faiza Shafiq

menopause dermal white adipose tissue dWAT estrogen adipogenic pathways adipogenesis magnolol PLLA-SCA dermal thickness skin elasticity skin plumpness skin texture skin rejuvenation

Studysummary This study reviewed evidence suggesting that the loss of dermal white adipose tissue (dWAT) during menopause may be linked to decreased estrogen levels, potentially affecting skin health, and discussed non-hormonal treatments, like magnolol, that might help restore dWAT and improve menopausal skin changes.

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research Defining Dermal Adipose Tissue

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