Adiponectin Serum Levels And ADIPOQ (rs2241766) Polymorphism In Alopecia Areata Egyptian Patients

November 2023 in “ Anais Brasileiros de Dermatologia ”

Azza Gaber Antar Farag, Eman Badr, Banan Mohamed Gamal Abd‐Elaty, Nada Farag Elnaidany, Mai Medhat Mohamed Ghanem

alopecia areata ADIPOQ gene rs2241766 polymorphism adiponectin TG genotype G allele AA

Studysummary This study suggests that the ADIPOQ gene polymorphism may influence the risk of alopecia areata in Egyptians, with adiponectin levels potentially serving as a marker for hair loss severity.

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The study suggests that the ADIPOQ (rs2241766) gene polymorphism, specifically the TG genotype and G allele, may influence the risk and development of alopecia areata (AA) in Egyptian populations. Additionally, lower levels of circulating adiponectin are implicated in the etiopathogenesis of AA and could serve as a marker for the severity of hair loss in affected individuals.

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research Alopecia Areata: A Multifactorial Autoimmune Condition

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research Trichoscopy of Alopecia Areata: An Update

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This study found that pro-inflammatory cytokines and apoptotic mechanisms, specifically involving granzyme B and Fas pathways, are associated with chronic alopecia areata, indicating their potential role in the disease's persistence.