Dermal White Adipose Tissue Enhances Proliferation, Pigmentation, and Hair Shaft Elongation in Human Hair Follicles Ex Vivo

May 2018 in “ Journal of Investigative Dermatology ”

Carina Nicu, J. Pople, Ranjit Bhogal, David M. Ansell, Ralf Paus

dermal white adipose tissue DWAT hair follicle HF cell proliferation melanin hair shaft elongation paracrine signaling scalp fat tissue hair growth pigmentation hair lengthening cell growth skin signaling

TLDR Fat under the skin can help hair grow longer, darker, and increase cell growth.

The study explored the impact of dermal white adipose tissue (DWAT) on human hair follicle (HF) functions. It was found that HFs cultured with DWAT exhibited increased cell proliferation, higher melanin content, and greater hair shaft elongation compared to HFs cultured alone. These enhancements suggest that DWAT may affect scalp HFs through paracrine signaling, which could be significant in understanding and treating hair disorders. The study did not specify the number of participants, as it was conducted ex vivo with micro-dissected human scalp HFs.

View this study on jidonline.org →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community The Big Fat Layer II

in Research/Science 26 upvotes 3 years ago

Hair loss treatment should target dermal white adipose tissue (DWAT) to restore hair follicles. Potential remedies include tocopherol (vitamin E), botox, rosiglitazone, niacin, kojyl cinnamate esters, and ADP355.

community The Big Fat Layer / Remedies: Cetirizine

in Treatment 12 upvotes 3 years ago

Treating hair loss with various remedies, such as Cetirizine and the Big3 complex (minoxidil, finasteride, and RU58841), which have properties like adipogenic, anti-fibrotic and anti-inflammatory. References to research studies are also included.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community My opinions on hair treatment right now and in future

in Treatment 22 upvotes 4 years ago

Finasteride, minoxidil, dermarolling, and topical antiandrogens are effective for hair regrowth. Future treatments may include CB0301 and hair cloning.

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 98 upvotes 4 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

community 4.5 months/ Fin+Niz+Keto+Vitamins+Derm+Cold Water only washes

in Progress Pictures 622 upvotes 3 years ago

User achieved hair regrowth in 4.5 months using Fin, Min, Nizoral, vitamins, dermarolling, and cold water washes. Cold water washes improved scalp health, but unsure if significant contributor to regrowth.

Similar Research

5 / 1000+ results

research Recreation of a Hair Follicle Regenerative Microenvironment: Successes and Pitfalls

8 citations, May 2021 in “Bioengineering & translational medicine”

Hair growth environment recreated with challenges; stem cells make successful skin organoids.

research Cell of Origin Contributes to Melanoma Diversity

April 2018 in “Journal of Investigative Dermatology”

Different types of stem cells in the skin contribute to the variety of melanoma forms.

Decoding Frontal Fibrosing Alopecia and Lichen Planopilaris: Macrophages Hold the Key?