Decoding Frontal Fibrosing Alopecia and Lichen Planopilaris: Macrophages Hold the Key?

    April 2018 in “ Journal of Investigative Dermatology ”
    Matthew Harries, Jonathan A. Hardman, Ralf Paus
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    TLDR Macrophages are more involved in Lichen planopilaris than in Frontal fibrosing alopecia.
    The document reviews various studies on hair biology and disorders, highlighting the potential role of dermal white adipose tissue in hair growth, the discovery of stem cell clusters in the corneal epithelium, and the use of PPAR-y modulation as a treatment for scarring alopecia. Specifically, it focuses on a study examining the involvement of macrophages in frontal fibrosing alopecia (FFA) and Lichen planopilaris (LPP). This study found a significantly higher number of CD68+ macrophages in LPP than in FFA and control samples, suggesting a greater role in LPP's pathogenesis and indicating a difference between the pathogeneses of LPP and FFA. The document also touches on research into melanoma diversity and the molecular mechanisms of donor dominance in androgenetic alopecia, providing insights into the factors that affect hair follicle behavior and related diseases.
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