Advances In Polymeric Nano-Delivery Systems Targeting Hair Follicles For The Treatment Of Acne

July 2024 in “ Drug Delivery ”

Yujing Lei, Wanting Jiang, Cheng Peng, Donghai Wu, Jing Wu, Yiling Xu, Hong Yan, Xinhua Xia

polymeric nano-delivery systems hair follicles acne polymer-based nanocarriers transdermal penetration nanodrug-delivery systems

Studysummary This review discusses how polymer-based nanocarriers can enhance drug delivery targeting hair follicles for acne treatment, focusing on factors affecting this delivery method, combination technologies to improve follicle targeting, and recent advancements in polymer nanodrug-delivery systems.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The document explores the potential of polymeric nano-delivery systems targeting hair follicles for acne treatment, emphasizing their ability to bypass the skin's cuticle barrier. It reviews various polymer carriers, including polymer nanoparticles, micelles, nano-gels, and dendritic polymers, each offering unique drug delivery benefits. The study highlights the superior permeability of cationic polymers, despite their higher toxicity risks, and suggests strategies like embedding cationic nanocapsules in nanogels to mitigate these risks. It also discusses enhancing drug delivery through technologies like iontophoresis and microneedles. The paper underscores the need for further research to optimize these systems and explores future therapies such as acne immunotherapy and phage therapy. Additionally, it notes the potential of these systems for treating other follicle-derived conditions like alopecia.

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research Thymol-Loaded PLGA Nanoparticles: An Efficient Approach for Acne Treatment

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research Follicular-Targeted Delivery of Spironolactone Provided by Polymeric Nanoparticles

18 citations , September 2021 in “Colloids and surfaces. B, Biointerfaces”

This study explored the development of polymeric nanoparticles for topical spironolactone delivery, finding that larger nanoparticles (180 nm) enhanced drug targeting to hair follicles significantly more than smaller ones or non-nanoparticle formulations, offering promise for safer acne and alopecia treatments.

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research Polymeric Micelle Mediated Follicular Delivery of Spironolactone: Targeting the Mineralocorticoid Receptor to Prevent Glucocorticoid-Induced Activation and Delayed Cutaneous Wound Healing

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This study found that polymeric micelle nanocarriers delivered pharmacologically relevant amounts of spironolactone to the epidermis and upper dermis, with higher delivery to pilosebaceous units, suggesting potential for treating glucocorticoid-induced impaired wound healing and pilosebaceous androgen-related skin diseases.

research Recreation of a Hair Follicle Regenerative Microenvironment: Successes and Pitfalls

8 citations , May 2021 in “Bioengineering & translational medicine”

This review examines the challenges of hair follicle regeneration and outlines strategies for bioengineering human hair follicle models, without presenting new experimental results.

An Updated Review of the Sebaceous Gland and Its Role in Health and Diseases Part 2: Pathophysiological Clinical Disorders of Sebaceous Glands

research An Updated Review of the Sebaceous Gland and Its Role in Health and Diseases Part 2: Pathophysiological Clinical Disorders of Sebaceous Glands

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This review discusses various pathologies involving sebaceous glands, primarily and secondarily, but reports no new clinical findings.

research Thiolated and PEGylated Silica Nanoparticle Delivery to Hair Follicles

16 citations , November 2020 in “International journal of pharmaceutics”

This study found that PEGylation of nanoparticles enhances their penetration into hair follicles, with higher molecular weight PEG resulting in deeper follicular delivery.

research Hair Follicle Targeting With Curcumin Nanocrystals: Influence of Formulation Properties on Penetration Efficacy

60 citations , October 2020 in “Journal of Controlled Release”

This study found that curcumin nanocrystals efficiently penetrated hair follicles down to the lower infundibulum in an ex-vivo pig ear model, regardless of the gel vehicle used, though passive dermal penetration varied with the vehicle’s skin hydrating properties.

research Dutasteride Nanocapsules for Hair Follicle Targeting: Effect of Chitosan-Coating and Physical Stimulus

26 citations , February 2020 in “International Journal of Biological Macromolecules”

This study demonstrates that massage significantly enhances the follicular targeting of dutasteride-loaded nanocapsules, increasing drug accumulation in hair follicles by up to 5 times.

research Selective Delivery of Adapalene to the Human Hair Follicle Under Finite Dose Conditions Using Polymeric Micelle Nanocarriers

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This study found that polymeric micelle formulations significantly improved the targeted delivery of adapalene to hair follicles compared to standard Differin® products, which suggests potential advantages in treating hair follicle-related conditions and reducing side effects.

research Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men – Short Version

145 citations , November 2017 in “Journal of The European Academy of Dermatology and Venereology”

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research Iontophoretic Transdermal Delivery Using Chitosan-Coated PLGA Nanoparticles for Positively Charged Drugs

64 citations , October 2017 in “Colloids and surfaces. B, Biointerfaces”

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research Skin Permeability and Transdermal Delivery Route of 50-nm Indomethacin-Loaded PLGA Nanoparticles

39 citations , August 2017 in “Colloids and Surfaces B: Biointerfaces”

This study found that 50-nm PLGA nanoparticles delivered with iontophoresis enhanced skin permeation of indomethacin in rats more effectively than 100-nm nanoparticles, suggesting improved targeting of hair follicles.

Mechanistic Analysis of Human Skin Distribution and Follicular Targeting of Adapalene-Loaded Biodegradable Nanospheres With Insight Into Hydrogel Matrix Influence, In Vitro Skin Irritation, and In Vivo Tolerability

research Mechanistic Analysis of Human Skin Distribution and Follicular Targeting of Adapalene-Loaded Biodegradable Nanospheres With Insight Into Hydrogel Matrix Influence, In Vitro Skin Irritation, and In Vivo Tolerability

17 citations , June 2017 in “Journal of pharmaceutical sciences”

This study found that adapalene-loaded nanospheres in a hyaluronic acid gel enhanced skin penetration and were nonirritant, making them potentially suitable for treating acne on oily skin.

research Dendritic Polyglycerol and N-Isopropylacrylamide Based Thermoresponsive Nanogels as Smart Carriers for Controlled Delivery of Drugs Through the Hair Follicle

62 citations , November 2016 in “Nanoscale”

In this study, researchers developed thermoresponsive nanogels that effectively penetrate hair follicles and release a model drug when triggered by temperature, demonstrating greater penetration for medium to large nanogels (300–500 nm) compared to smaller ones.

research Development and Characterization of Polymeric Nanoparticle-Based Formulation of Adapalene for Topical Acne Therapy

42 citations , August 2016 in “Nanomedicine”

In this study, TyroSpheres were used to encapsulate adapalene, increasing its solubility and enhancing skin distribution while reducing irritancy compared to a commercial formulation, indicating promise for acne treatment in ex vivo and in vitro settings.

Mechanistic Study of Decreased Skin Penetration Using a Combination of Sonophoresis with Sodium Fluorescein-Loaded PEGylated Liposomes with D-Limonene

research Mechanistic Study of Decreased Skin Penetration Using a Combination of Sonophoresis with Sodium Fluorescein-Loaded PEGylated Liposomes with D-Limonene

6 citations , December 2015 in “International journal of nanomedicine”

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research Applications and Limitations of Lipid Nanoparticles in Dermal and Transdermal Drug Delivery via the Follicular Route

95 citations , July 2015 in “European journal of pharmaceutics and biopharmaceutics”

This review discusses the application of lipid nanoparticles for enhancing drug delivery through hair follicles and reports no new clinical results, emphasizing the potential role of sebum-like lipids in this context.

research Self-Assembled Polymeric Nanocarriers for the Targeted Delivery of Retinoic Acid to the Hair Follicle

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research Polymeric Micelle Nanocarriers for the Cutaneous Delivery of Tacrolimus: A Targeted Approach for the Treatment of Psoriasis

159 citations , July 2014 in “Molecular pharmaceutics”

This study found that MPEG-dihexPLA micelles significantly improved the skin deposition of tacrolimus compared to a marketed ointment, suggesting better targeted delivery with reduced systemic absorption.

research Polymeric Nanoparticles-Embedded Organogel for Roxithromycin Delivery to Hair Follicles

47 citations , July 2014 in “European Journal of Pharmaceutics and Biopharmaceutics”

This study concluded that polymeric nanoparticles effectively targeted hair follicles for drug delivery, but the organogel formulation did not enhance their penetration into the hair shaft.

research Human Hair Follicle: Reservoir Function and Selective Targeting

97 citations , September 2011 in “British Journal of Dermatology”

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research Novel Micelle Formulations to Increase Cutaneous Bioavailability of Azole Antifungals

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research Selective Follicular Targeting by Modification of the Particle Sizes

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research Nanoparticle-Based Targeting of Vaccine Compounds to Skin Antigen-Presenting Cells by Hair Follicles and Their Transport in Mice

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research 40nm, But Not 750 or 1,500nm, Nanoparticles Enter Epidermal CD1a+ Cells After Transcutaneous Application on Human Skin

323 citations , April 2006 in “The journal of investigative dermatology/Journal of investigative dermatology”

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