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    Glossary T helper 17 cells

    specialized immune cells involved in inflammation and autoimmune responses

    T helper 17 cells, often abbreviated as Th17 cells, are a subset of T cells, which are a type of white blood cell crucial for the immune system. Th17 cells play a key role in defending the body against bacterial and fungal infections by producing a specific set of signaling molecules called cytokines, particularly interleukin-17 (IL-17). They are also involved in inflammatory responses and have been implicated in various autoimmune diseases, where the immune system mistakenly attacks the body's own tissues.

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    1. T helper 17 cell/regulatory T-cell imbalance in hidradenitis suppurativa/acne inversa: the link to hair follicle dissection, obesity, smoking and autoimmune comorbidities 2018 · 66 citations
    2. Imbalance of T‐helper 17 and regulatory T cells in patients with alopecia areata The Journal of Dermatology · 2015 · 62 citations
    3. 42905 Role of regulatory T and T-helper 17 cells in patients with acute diffuse and total alopecia Journal of the American Academy of Dermatology · 2023
    4. MicroRNA-1246 Inhibits NFATc1 Phosphorylation and Regulates T Helper 17 Cell Activation in the Pathogenesis of Severe Alopecia Areata 2023
    5. The Role of T‐Helper 17 Cells and Regulatory T Cells in Acute Diffuse and Total Alopecia: The Increased Function of Regulatory T Cells May Explain the Favorable Prognosis The Journal of Dermatology · 2025 · 1 citations
    6. Detection of subtypes of T helper cells and their cytokines in peripheral blood of patients with systematic lupus erythematosus and their clinical significances Journal of Jilin University · 2014
    7. T Cells Promote Distinct Transcriptional Programs of Cutaneous Inflammatory Disease in Keratinocytes and Dermal Fibroblasts Journal of Investigative Dermatology · 2025 · 2 citations
    8. The potential of regulatory T cell-based therapies for alopecia areata Frontiers in Immunology · 2023
    9. Role of regulatory T cells in psoriasis pathogenesis and treatment British Journal of Dermatology · 2020 · 273 citations
    10. CD4 T cells from mice with alopecia areata express an effector like phenotype and can transfer disease The Journal of Immunology · 2023 · 1 citations
    11. Class IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation Proceedings of the National Academy of Sciences · 2024 · 16 citations
    12. Targeting lymphoid-derived IL-17 signaling to delay skin aging Nature Aging · 2023 · 59 citations
    13. Local IL-17 orchestrates skin aging bioRxiv (Cold Spring Harbor Laboratory) · 2022 · 1 citations
    14. An ROS‐Scavenging Treg‐Recruiting Hydrogel Patch for Diabetic Wound Healing Advanced Functional Materials · 2024
    15. Identification of Biomarkers in Affected Hair Follicles from Chronic Discoid LupusErythematosus by Weighted Gene Co-Expression Network Analysis Research Square (Research Square) · 2022
    16. Identification of Biomarkers in Affected Hair Follicles from Chronic Discoid Lupus Erythematosus by Weighted Gene Co-Expression Network Analysis Research Square (Research Square) · 2022
    17. Essential Role of STAT3 Signaling in Hair Follicle Homeostasis Frontiers in immunology · 2021 · 6 citations
    18. The effect of 5-α reductase inhibitor on Th1, Th2, and Th17 cell-related inflammatory response in BPH World Journal of Urology · 2023 · 1 citations
    19. Hepatitis C‐related mixed type vitiligo in a patient with Ivemark syndrome The Journal of Dermatology · 2014 · 1 citations
    20. Improved humoral immunity and protection against influenza virus infection with a 3D porous biomaterial vaccine bioRxiv (Cold Spring Harbor Laboratory) · 2022
    21. Regulatory T cells modulate bone marrow stromal cell osteogenesis by activating ROCK-myosin axis and cell contractility 2026
    22. The imbalance between Type 17 T-cells and regulatory immune cell subsets in psoriasis vulgaris Frontiers in Immunology · 2022 · 49 citations
    23. γδ17 T cell-stromal networks modulate matrix composition and vascularity in foreign body response 2026 · 1 citations
    24. The Phenotype of Circulating Follicular-Helper T Cells in Patients with Rheumatoid Arthritis Defines CD200 as a Potential Therapeutic Target Clinical & Developmental Immunology · 2012 · 32 citations
    25. Evaluation of platelet-rich plasma on hair regrowth and lesional T-cell cytokine expression in alopecia areata: A randomized observer-blinded, placebo-controlled, split-head pilot study Journal of The American Academy of Dermatology · 2020 · 9 citations
    26. Perforins Expression by Cutaneous Gamma Delta T Cells Frontiers in Immunology · 2020 · 13 citations
    27. Silicate-based therapy for inflammatory dilated cardiomyopathy by inhibiting the vicious cycle of immune inflammation via FOXO signaling Science Advances · 2025 · 7 citations
    28. Plain language summaries British Journal of Dermatology · 2016
    29. Altered expression of intracellular Toll-like receptors in peripheral blood mononuclear cells from patients with alopecia areata BBA clinical · 2016 · 12 citations
    30. CLINICAL AND LABORATORY EVALUATION OF AIDS TRICHOPATHY International Journal of Dermatology · 1993 · 35 citations