Regulatory Gamma Delta T Cells Protect Human Scalp Hair Follicles From Alopecia Areata In Vivo

    September 2024 in “ Journal of the American Academy of Dermatology ”
    Aviad Keren, Nyra Goldstein, Marta Bertolini, R. Kassem, Ralf Paus, Amos Gilhar
    Image of study
    TLDR Regulatory γδ T cells help protect hair follicles from alopecia areata and promote hair regrowth.
    This study investigates the role of Foxp3+ γδ regulatory T cells (γδTregs) in protecting human scalp hair follicles from alopecia areata (AA). The researchers found an increased frequency of TCRVδ1/Foxp3 cells in the lesional skin of AA patients. They generated autologous human γδTregs and tested their effects in humanized AA mice and organ-cultured human scalp hair follicles. In vivo, γδTreg injections prevented AA induction and promoted hair regrowth in established lesions, restoring hair follicle immune privilege. Ex vivo, γδTregs reduced expression of immune privilege collapse markers and increased proliferation of hair matrix keratinocytes. The study suggests γδTregs as potential cell-based therapeutics for AA management.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results
      Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      in Research  864 upvotes 4 months ago
      The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

      community How does dutasteride regrowth work?

      in Finasteride/Dutasteride  6 upvotes 9 months ago
      A 25-year-old man with hair loss from bleach damage is using oral minoxidil and considering adding Dutasteride for better regrowth and prevention. He seeks advice on Dutasteride's effectiveness and potential benefits over finasteride, and is also curious about RU58841.

      community Fats on your Head to Stop Hair Loss?

      in Research/Science  140 upvotes 1 year ago
      The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

      community Alopecia Areata Question

      in Treatment  2 upvotes 3 years ago
      A user with alopecia totalis, borderline universalis, seeks advice on getting into a Xeljanz trial or appealing insurance for coverage. They experienced significant hair regrowth but are now seeing hair loss again and want to try Xeljanz.

      community mbp alopecia areata or vitamin deficiency

      in Chat 8 months ago
      A 19-year-old male has been using topical finasteride and minoxidil for 8 months with no progress and is considering seeking a second opinion due to potential misdiagnosis. The discussion revolves around whether the hair loss is due to male pattern baldness, alopecia areata, or a vitamin deficiency.

      community Olumiant alternative for Alopecia Areata?

      in Treatment  1 upvotes 1 year ago
      A user with alopecia areata is considering treatment options like injections or Olumiant but is concerned about cost and whether delaying treatment will lead to permanent hair loss. They are seeking alternative treatments that are more affordable for a college student.

    Related Research

    4 / 4 results