Regulatory Gamma Delta T Cells Protect Human Scalp Hair Follicles From Alopecia Areata In Vivo

    September 2024 in “ Journal of the American Academy of Dermatology ”
    Aviad Keren, Nyra Goldstein, Marta Bertolini, R. Kassem, Ralf Paus, Amos Gilhar
    Image of study
    TLDR Regulatory γδ T cells help protect hair follicles from alopecia areata and promote hair regrowth.
    The study investigates the role of Foxp3+ γδ regulatory T cells (γδTregs) in protecting human scalp hair follicles from alopecia areata (AA). Researchers found an increased frequency of TCRVδ1/Foxp3 cells in AA patients' lesional skin. By generating autologous human γδTregs and injecting them into AA lesions on human scalp skin xenotransplants in mice, they observed prevention of AA onset and strong hair regrowth in established lesions. This was accompanied by reduced perifollicular infiltrate and restoration of hair follicle immune privilege. Ex vivo, γδTregs reduced expression of immune privilege collapse markers and premature catagen induction, while increasing proliferation and decreasing apoptosis of hair matrix keratinocytes. The study highlights γδTregs as crucial AA-protective immune cells and potential candidates for cell-based therapies in AA management.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Alopecia Areata Question

      in Treatment  2 upvotes 3 years ago
      A user with alopecia totalis, borderline universalis, seeks advice on getting into a Xeljanz trial or appealing insurance for coverage. They experienced significant hair regrowth but are now seeing hair loss again and want to try Xeljanz.

      community mbp alopecia areata or vitamin deficiency

      in Chat 3 months ago
      A 19-year-old male has been using topical finasteride and minoxidil for 8 months with no progress and is considering seeking a second opinion due to potential misdiagnosis. The discussion revolves around whether the hair loss is due to male pattern baldness, alopecia areata, or a vitamin deficiency.

      community Olumiant alternative for Alopecia Areata?

      in Treatment  1 upvotes 1 year ago
      A user with alopecia areata is considering treatment options like injections or Olumiant but is concerned about cost and whether delaying treatment will lead to permanent hair loss. They are seeking alternative treatments that are more affordable for a college student.

    Related Research

    4 / 4 results