Hepatitis C-Related Mixed Type Vitiligo in a Patient with Ivemark Syndrome

    January 2014 in “ The Journal of Dermatology ”
    Noriko Hashimoto, Atsushi Tanemura, Miki Yamada, Saori Itoi, Ichiro Katayama
    Image of study
    TLDR A patient with Ivemark syndrome developed mixed type vitiligo after a hepatitis C infection, showing different treatment responses and immune cell involvement in the skin.
    In the documented case, a 31-year-old female with Ivemark syndrome—a rare congenital disorder characterized by spleen and heart malformations—developed mixed type vitiligo after being infected with hepatitis C virus from a blood transfusion. The patient exhibited different responses to excimer light treatment between non-segmental and segmental vitiligo lesions, with over 75% repigmentation in non-segmental lesions but insufficient improvement in segmental lesions. Immunohistochemical analysis revealed a notable infiltration of CD8+ T cells and CD4+/interleukin-17A+ T-helper (Th)17 cells, as well as an expansion of CD1a+ Langerhans cells in non-segmental lesions compared to segmental ones. This suggests that hepatitis C infection may influence the immune response and contribute to the development of non-segmental vitiligo. This case is the first reported instance of mixed type vitiligo in a patient with both Ivemark syndrome and hepatitis C, indicating a coexistence of different pathological conditions in mixed vitiligo.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 7 results

      community One full year of treatment before and after

      in Progress Pictures  18 upvotes 4 months ago
      A user shared their one-year progress with hair loss treatment, using topical minoxidil, 2% keto shampoo, microneedling, and finasteride. They plan to start dutasteride and are considering switching to oral minoxidil.

      community Quit vaping/smoking = 80% less loss

      in Research/Science  235 upvotes 8 months ago
      Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.

      community Fighting Hair loss AND Grey Hair

      in Treatment  18 upvotes 2 years ago
      The user is treating hair loss with topical Minoxidil, Finasteride, RU58841, microneedling, and Ketoconazole. For grey hair, they use L-Cysteine, L-Methionine, and PABA, and have noticed some re-pigmentation.

      community fin 0.5 mg everday 6 months update

      in Finasteride/Dutasteride  28 upvotes 1 year ago
      The post discusses the experiences of individuals with diffuse hair thinning using finasteride, with many reporting no improvement or worsening conditions after 6 months. Various suggestions include persisting with the treatment, checking for underlying conditions, adding minoxidil for volume, adjusting dosage, and considering other potential causes like autoimmune responses and inflammation.

      community 1 Month Topical Minoxidil Only

      in Progress Pictures  72 upvotes 1 year ago
      The conclusion of the conversation is that the user plans to use topical minoxidil, ketoconazole shampoo, and a derma stamp for hair loss treatment. They also plan to start using finasteride in the next 2 months. Other users suggest using finasteride and a hair transplant for better results. The user appreciates the feedback and will continue posting progress.

    Similar Research

    5 / 1000+ results