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GlossarySegmental Vitiligo

localized skin depigmentation affecting one body segment

Segmental Vitiligo is a type of vitiligo characterized by the loss of skin color in patches, typically affecting only one side or segment of the body. Unlike the more common generalized vitiligo, segmental vitiligo often appears at a younger age and progresses for a few years before stabilizing. It is believed to be associated with the nervous system, and the depigmented patches usually follow a dermatomal distribution, which is the area of skin supplied by a single spinal nerve.

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research Disorders of Pigmentation in Infants and Children

2 citations , January 2002 in “Clinics in Dermatology”

Vitiligo causes white skin patches, often starts before age 20, and is linked to other health issues.

research Segmental Vitiligo: Characteristics, Treatment, and Prognosis

2 citations , January 2019 in “Springer eBooks”

Segmental Vitiligo is a stable, early-onset form of vitiligo that responds well to early treatment and is ideal for repigmentation studies.

research Preservation of Melanoblasts in White Hair Follicles of Segmental Vitiligo Lesions: A Preliminary Study

7 citations , May 2010 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

White hair follicles in vitiligo have fewer and less functional melanocytes.

research Neurological Mechanisms Exploration and Therapeutic Targets in Segmental Vitiligo Accompanied by White Hair

1 citations , April 2025 in “Pigment Cell & Melanoma Research”

Managing stress and nerve activity can help treat segmental vitiligo and white hair.

research Therapeutic Success of Epidermal Grafting in Generalized Vitiligo Is Limited by the Koebner Phenomenon

84 citations , January 1990 in “Journal of The American Academy of Dermatology”

Skin grafting can help repigment vitiligo, but it's less effective for widespread cases due to the Koebner phenomenon.

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community One full year of treatment before and after

in Progress Pictures 18 upvotes 1 year ago

A user shared their one-year progress with hair loss treatment, using topical minoxidil, 2% keto shampoo, microneedling, and finasteride. They plan to start dutasteride and are considering switching to oral minoxidil.

community When someone posts a scalp tension theory

in Satire 264 upvotes 4 years ago

Hair loss theories discussed include poor blood flow, scalp tension, inflammation, and DHT. Treatments mentioned are massaging scalp, minoxidil, finasteride, and RU58841.

community The story of RU58841/ PSK3841

Typical-Promise-3001 in Research 622 upvotes 1 year ago

RU58841, a potential hair loss treatment, was not commercialized due to marketability issues and lack of long-term safety data. Concerns about its formulation and delivery methods further complicate its use.

community Evaluate your progress with an objective tool

in Progress Pictures 40 upvotes 1 year ago

The post discusses using ImageJ software to objectively track hair regrowth progress. The user is treating Androgen alopecia with dutasteride and minoxidil.

community Guide To Finasteride and Avoiding Side Effects

in Finasteride/Dutasteride 26 upvotes 3 years ago

The conversation provides a guide on using finasteride for hair loss, suggesting to start with a quarter of a 1mg pill daily after ensuring estradiol levels are within a specific range, and potentially increasing the dose if no side effects occur. It also recommends supplements like DIM, Calcium d-glucarate, and Zinc to manage high estradiol levels and side effects from finasteride.

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