Neurological Mechanisms Exploration and Therapeutic Targets in Segmental Vitiligo Accompanied by White Hair

    Shiqi Fu, Bo Xie, Xiuzu Song
    Studysummary This article reviews the underlying mechanisms of segmental vitiligo with white hair, focusing on skin and hair follicle melanocytes, and proposes potential targets for treatment, highlighting neuroendocrine factors as possible contributors to the condition.
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    Research cited in this study 12

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    2. The biology of human hair greying Biological reviews/Biological reviews of the Cambridge Philosophical Society · 2020
    3. Hyperactivation of Sympathetic Nerves Drives Depletion of Melanocyte Stem Cells Nature · 2020
    4. Regulation of Melanocyte Stem Cells in the Pigmentation of Skin and Its Appendages: Biological Patterning and Therapeutic Potentials Experimental Dermatology · 2018
    5. An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin Developmental cell · 2015
    6. Age-Induced Hair Greying: The Multiple Effects of Oxidative Stress International Journal of Cosmetic Science · 2013
    7. Repigmentation of Poliosis After Epithelial Grafting for Vitiligo Dermatologic Surgery · 2013
    8. Sudden Whitening of the Hair in an 82-Year-Old Woman: The 'Overnight Greying' Phenomenon Clinical and Experimental Dermatology · 2012
    9. Preservation of Melanoblasts in White Hair Follicles of Segmental Vitiligo Lesions: A Preliminary Study JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2010
    10. Neuronal Plasticity of the Brain-Skin Connection: Stress-Triggered Up-Regulation of Neuropeptides in Dorsal Root Ganglia and Skin via Nerve Growth Factor-Dependent Pathways Journal of Molecular Medicine · 2007
    11. Stress Exposure Modulates Peptidergic Innervation and Degranulates Mast Cells in Murine Skin Brain Behavior and Immunity · 2004
    12. Neurogenic Inflammation in Stress-Induced Termination of Murine Hair Growth Is Promoted by Nerve Growth Factor American Journal of Pathology · 2004