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    Glossary spheroids

    three-dimensional cell clusters used for more accurate tissue studies

    Spheroids are three-dimensional cell cultures that mimic the structure and function of tissues more accurately than traditional two-dimensional cultures. In the context of hair and alopecia research, spheroids can be used to study hair follicle biology and test potential treatments in a more physiologically relevant environment.

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    1. Scalable production of controllable dermal papilla spheroids on PVA surfaces and the effects of spheroid size on hair follicle regeneration Biomaterials · 2012 · 78 citations
    2. Using bioprinting and spheroid culture to create a skin model with sweat glands and hair follicles Burns & Trauma · 2021 · 65 citations
    3. Controllable Production of Transplantable Adult Human High-Passage Dermal Papilla Spheroids Using 3D Matrigel Culture Tissue engineering. Part A · 2014 · 46 citations
    4. Enhanced viability and neural differential potential in poor post-thaw hADSCs by agarose multi-well dishes and spheroid culture Human Cell · 2015 · 15 citations
    5. TGF-β2 and collagen play pivotal roles in the spheroid formation and anti-aging of human dermal papilla cells Aging · 2021 · 11 citations
    6. Generation and integration of hair follicle-primed spheroids in bioengineered skin constructs Biomedical Materials · 2022 · 8 citations
    7. Engineering Spatially Organized Hair Peg-like Structures in Human Skin Constructs Using Keratinocyte–Dermal Papilla Fibroblast Spheroids and Micropatterned Dermal Scaffolds Acta Biomaterialia · 2026
    8. 812 Multi-view light sheet florescence microscopy (LSFM) for imaging cellular self-assembly in spheroids of human hair follicle dermal papilla cells and keratinocytes Journal of Investigative Dermatology · 2020
    9. Spheroid transplantable and functional retinal pigment epithelium derived from non-colony dissociated human induced pluripotent stem cells Research Square (Research Square) · 2020
    10. Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne Cochrane library · 2009 · 112 citations
    11. Systemic Steroids With or Without 2% Topical Minoxidil in the Treatment of Alopecia Areata Archives of Dermatology · 1992 · 101 citations
    12. Role of Transepidermal and Transfollicular Routes in Percutaneous Absorption of Steroids: In vitro Studies on Human Skin Skin Pharmacology and Physiology · 1994 · 82 citations
    13. Anabolic androgenic steroids and carcinogenicity focusing on Leydig cell: a literature review Oncotarget · 2018 · 65 citations
    14. Local Injection of Steroids and Hair Regrowth in Alopecias Archives of Dermatology · 1960 · 57 citations
    15. GC-MS determination of steroids related to androgen biosynthesis in human hair with pentafluorophenyldimethylsilyl–trimethylsilyl derivatisation The Analyst · 1999 · 56 citations
    16. STEROIDS AND STEROID-LIKE COMPOUNDS Clinics in Sports Medicine · 1999 · 55 citations
    17. Anabolic-androgenic steroids and cardiovascular risk Chinese Medical Journal · 2019 · 38 citations
    18. The use of liposomes in the topical application of steroids Journal of Pharmacy and Pharmacology · 1984 · 33 citations
    19. Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne 2003 · 32 citations
    20. Effects of anabolic-androgenic steroids on the pilosebaceous unit. PubMed · 1992 · 16 citations
    21. Systemic Steroids for Treatment of Alopecia Areata Archives of Dermatology · 1977 · 9 citations
    22. The gut‐microbiota‐brain axis: Focus on gut steroids Journal of Neuroendocrinology · 2024 · 8 citations
    23. A quantitative ultra-performance liquid chromatography high-resolution mass spectrometry analysis of steroids from human scalp hair Journal of pharmaceutical and biomedical analysis · 2022 · 7 citations
    24. Simultaneous Determination of Selected Steroids with Neuroactive Effects in Human Serum by Ultrahigh-Performance Liquid Chromatography–Tandem Mass Spectrometry ACS Chemical Neuroscience · 2024 · 5 citations
    25. Medical consequences of long-term anabolic-androgenic Steroids (AASs) abuses in athletes Biomedical Research-tokyo · 2017 · 5 citations
    26. Steroids excreted by human skin. I. C19-steroids in axillary hair. PubMed · 1983 · 5 citations
    27. Steroids and the Skin: A General Review Biochemical Society transactions · 1976 · 5 citations
    28. Measuring steroids in hair opens up possibilities to identify congenital adrenal hyperplasia in developing countries Clinical endocrinology · 2022 · 3 citations
    29. Serial Hydrolysis for the Simultaneous Analysis of Catecholamines and Steroids in the Urine of Patients with Alopecia Areata Molecules · 2021 · 2 citations
    30. Why steroids may not always work in alopecia areata: elevated unoccupied glucocorticoid receptors and decreased levels of thioredoxin Dermatologic Therapy · 2001 · 2 citations