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Glossary Cell Aggregates

groups of cells that adhere together forming a mass

Cell aggregates, also known as cell clusters, are groups of cells that adhere to each other, forming a mass. These aggregates can occur naturally in the body, such as in the formation of tissues and organs, or can be created in a laboratory setting for research purposes. In the context of hair and alopecia, cell aggregates might be studied to understand how hair follicles develop and how they can be regenerated or repaired.

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Research

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The Enhancement of Dermal Papilla Cell Aggregation by Extracellular Matrix Proteins Through Effects on Cell–Substratum Adhesivity and Cell Motility

research The enhancement of dermal papilla cell aggregation by extracellular matrix proteins through effects on cell–substratum adhesivity and cell motility

44 citations , June 2009 in “Biomaterials”

In this study, fibronectin coating on a low-adhesive substratum increased cell aggregation, growth, and motility, enhancing the formation of hair follicle dermal papilla spheroids.

research Human iPS Cell-Derived Cell Aggregates Exhibited Dermal Papilla Cell Properties in in vitro Three-Dimensional Assemblage Mimicking Hair Follicle Structures

10 citations , August 2021 in “Frontiers in cell and developmental biology”

This study suggests the possibility of regenerating hair follicle structures in vitro using hiPSC-derived cell composites, which might reduce reliance on human tissue-derived cells for hair bioengineering.

research Rapid Formation of Cell Aggregates and Spheroids Induced by a “Smart” Boronic Acid Copolymer

26 citations , August 2016 in “ACS Applied Materials & Interfaces”

In this study, cell membrane remodeling with a thermoresponsive boronic acid copolymer was shown to rapidly form spheroids from cancer or cardiac cell lines under standard conditions, promising advances in tissue engineering.

research Canine Adipose-Derived Stem Cell Aggregates as a Viable Substitute to Actual Canine Dermal Papillae

4 citations , May 2015 in “Macedonian Veterinary Review”

This study found that dermal papilla-like tissue reconstructed using canine adipose-derived mesenchymal stem cells closely resembles actual canine dermal papilla cells in both morphology and molecular characteristics.

research Author response: Hair follicle dermal condensation forms via Fgf20 primed cell cycle exit, cell motility, and aggregation

1 citations , July 2018

In this study, Fgf20 was found to trigger movement and morphogenesis in dermal fibroblasts, facilitating dermal condensate formation essential for hair follicle development.

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Community Join

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community I built a tracker for every hair loss treatment in clinical development

in Research/Science 92 upvotes 8 months ago

A user created a tracker for hair loss treatments in clinical development, including compounds like Dermaliq, RU58841, and Pyrilutamide. The tracker updates with new information and allows filtering by conditions like androgenetic alopecia (AGA) and alopecia areata (AA).

community A stress hormone has been found to signal through skin cells to repress the activation of hair-follicle stem cells in mice

30 upvotes 5 years ago

Stress can lead to hair loss by affecting hair-follicle stem cells, and this loss is harder to recover from if one has male pattern baldness (MPB). Treatments like finasteride and minoxidil are used to address hair loss, but stress-related hair loss differs from androgenic alopecia.

community Cell senescence-targeted treatment for hair loss, has anyone tried any products/enzymes etc. that use this theory

5 upvotes 1 year ago

DHT causes hair loss by driving cells into senescence, and a polyphenol in black chokeberry may reverse this. A product using this theory is being considered for use alongside finasteride, minoxidil, and microneedling.

community Has anyone here actually undergone experimental (grey market) hair cell therapy/follicle cloning?

7 upvotes 5 months ago

Hair cell therapy and follicle cloning are still in experimental stages, with treatments like hair multiplication and regenerative hair therapy being marketed but not yet proven to create unlimited new follicles. There is skepticism about the effectiveness and legitimacy of these treatments, with some considering them scams.

community What do you guys think of stem cell hai restoration?

10 upvotes 8 months ago

Stem cell hair restoration lacks scientific evidence and is often considered a scam. Effective hair loss treatments include hair transplants, Minoxidil, and Finasteride, but stem cell treatments are not proven.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Stem Cell Factor

What is stem cell factor and why is it used in hair growth treatments? Stem cell factor promotes hair growth by signaling cell survival and division.
How does stem cell factor help activate dormant hair follicles? Stem cell factor activates dormant hair follicles by signaling through the c-Kit receptor.
Are stem cell factor products safe for long-term scalp use? Stem cell factor products lack proven long-term safety for scalp use.
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learn Apple stem cell

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Clinics

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