High-Throughput Screening of 3D Co-Culture Hair Follicle Mimetic Tissue with Enhanced ECM for the Screening of Hair Growth Promoting Compounds

    January 2024 in “ Biomaterials Research ”
    Huyen T. M. Pham, Hyo-Sop Kim, Duc Long Nguyen, Hyun Woo Joo, Min Kyu Kim, Young Kwan Sung, Duc Vu, Heung Sik Hahm, Se Joo Kim, Jae‐Ho Kim, Hyun‐Ji Park
    Image of study
    TLDR The new 3D system helps test hair growth treatments effectively.
    The study introduces a novel 3D co-culture system that mimics the in vivo extracellular matrix (ECM) dynamics crucial for hair follicle development and regeneration. This system uses primary dermal papilla cells from human patients co-cultured with neonatal keratinocytes, forming uniform spheroids that closely resemble native ECM structures. The model supports high-throughput screening, allowing for the evaluation of approximately 60 spheroids per well, and demonstrates consistent cellular organization and enhanced ECM-related gene expression. This platform provides a robust and reproducible method for assessing potential hair loss treatments, advancing the development of therapeutic candidates through effective epithelial-mesenchymal interactions.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 34 results
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 6 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community DIY PRP Scalp Injections - wish me luck!

      in Treatment  39 upvotes 4 years ago
      A user shared their experience with DIY PRP scalp injections for hair regrowth, using an EZ Injector and other at-home equipment. Another user reported success with at-home PRP treatments for 1.5 years, noting thicker hair and a stable hairline.

      community Am I taking out too much foam for a dose? Rogaine Minoxidil

      in Minoxidil 1 year ago
      This conversation discusses the topical application of Minoxidil, with various users providing advice on how to accurately measure a dose and keep it from melting too quickly. Others have shared their experiences using oral finasteride for hair loss treatments.

      community Scalp Micropigmentation while having hair

      in Treatment  6 upvotes 2 years ago
      User discusses scalp micropigmentation for denser hair appearance and its benefits compared to lifelong treatments. Special ink is used, which can fade and blur over time but can be topped up.

    Related Research

    3 / 3 results