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Finasteride discontinuation increases sperm count in men.

In this study, three cases of young men using finasteride for five years showed altered sperm morphology and motility issues, with partial improvement observed after discontinuation.

This study found that prolonged use of finasteride and dutasteride in young men with androgenic alopecia is linked to a decline in semen quality over time, particularly affecting sperm motility and DNA integrity, with dutasteride showing a slightly greater impact than finasteride.

This study found that long-term use of dutasteride in men taking it for androgenetic alopecia may lead to persistent decreases in semen volume and sperm motility, potentially impacting fertility, with significant impairment observed after 17.8 to 20.3 months of treatment.

In this study on Sprague-Dawley rats, 0.60 mg/kg doses of L-Se-methylselenocysteine and sodium selenite were associated with liver toxicity and reduced sperm motility, while Se-enriched peptides showed no observable adverse effects up to 0.60 mg/kg.

In this study, topical application of a 10% minoxidil lotion on mature rats over 72 days was associated with reduced testis and epididymis mass and sperm motility, indicating potential gonadotoxic effects.

Finasteride daily doesn't affect sperm production or semen in young men.

In this study, researchers analyzed spermogram data from men with diagnosed infertility in Ukraine, aiming to identify the most common sperm disorders, and they found that the study primarily involved men with primary infertility, compared to a control group of healthy men with confirmed fertility.

This study observed that herbal feed supplementation in Frieswal breeding bulls improved semen volume and motility, while significantly lowering dihydrotestosterone levels, suggesting a potential mechanism for enhancing semen quality.

The April 2014 issue of "Fertility and Sterility" discussed various reproductive health topics, including hormone therapy benefits, sperm and genetic factors in male infertility, and the link between PCOS and diabetes.

This review reports that 5-alpha reductase inhibitors, used to treat androgenic alopecia, may adversely affect sperm count, sexual function, and hormones in a subset of patients.

This study highlights the need for a comprehensive andrological assessment at diagnosis, including semen and hormonal analysis, to guide fertility preservation strategies, and found that post-orchidectomy semen samples showed improved DNA integrity for assisted reproductive technologies.

In this study, administering 5alpha-reductase inhibitors reduced dihydrotestosterone levels and was associated with mild, reversible decreases in semen parameters in healthy men.

This review highlights potential negative impacts of certain medications on male fertility, such as hormonal disruption and germ cell toxicity, emphasizing the importance of clinicians being aware of these effects to advise on safer alternatives.

This article reviews the roles of lesser-known secreted phospholipase A2 isoforms in various biological processes, such as immune suppression, metabolic regulation, epidermal hyperplasia, and male reproduction, without reporting new clinical findings.

In this study, oral melatonin given to male Pomeranian dogs with Alopecia X improved semen quality and testicular blood flow in a dose-dependent manner, but altered hormonal balance, indicating complex effects that require further investigation for long-term implications.

This study suggests that 5α-reductase inhibitors do not significantly affect male reproductive function but may require caution in men with oligospermia or ejaculatory issues.

This study explored the effects of MOTILIPERM on infertility in a rat model with varicocele and oxidative stress, reporting its potential therapeutic efficacy.

Larger prostate size in older men may be linked to poorer semen quality and fertility issues.

This study found that 2-ethylhexanoic acid impaired fertility in Wistar rats and delayed postnatal development of pups, suggesting potential reproductive toxicity at certain dosages.

In this study, male patients treated with 150 mCi of radioactive iodine showed no negative impact on fertility, but long-term studies with larger groups are needed to further assess hormonal effects and sperm health after this treatment.

This case report suggests that discontinuing low-dose finasteride in a 48-year-old man led to a significant reduction in sperm DNA fragmentation index, indicating a possible link between finasteride and sperm DNA damage.

This review discusses the risk factors and implications of sperm aneuploidy in males, and it reports no new clinical results; the authors highlight the importance of personalized assessment in assisted reproduction.

This study found that Origanum vulgare extract improved testicular structure and function in mice against finasteride-induced damage by enhancing antioxidant defense and modulating gene expression related to apoptosis.

A thorough initial check-up is essential before sperm banking to ensure the best chance of preserving good quality sperm.

This review discusses various substances that can impact male fertility and stresses that products should be confirmed 'sperm-safe' through rigorous testing, not assumptions; it reports no new study results.

This study found that stem cell transplantation effectively reduced acute inflammation-induced testicular damage, suggesting potential for cell-based therapies in addressing male infertility.

This study found that discontinuing finasteride led to a significant increase in sperm counts for most men with reduced fertility, though hormone levels and other semen parameters remained unchanged.

In this case report, a male patient's semen parameters improved after discontinuing a 1-mg dose of finasteride, suggesting that stopping the medication may benefit infertile men with previous sperm production issues.

This case report describes a 40-year-old man whose secondary infertility, observed after prolonged finasteride use for hair loss, resolved following discontinuation of the drug, resulting in a live birth.