Systemic Subchronic Toxicity and Comparison of Four Selenium Nutritional Supplements by 90-Day Oral Exposure in Sprague-Dawley Rats

    September 2023 in “ Food and chemical toxicology ”
    Lamei Yu, Yanmei Li, Wen Qu, Yanhua Zheng, Xuejiao Chen, Su Fu, Jingjing Qu, Jie Tian, Shuiyuan Cheng, Xin Cong, Bolin Fan, Chunhong Wang
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    TLDR High doses of some selenium supplements caused liver and reproductive harm in rats.
    The study investigated the systemic subchronic toxicity of four selenium nutritional supplements (SeP, SeY, L-SeMc, and Na2SeO3) over a 90-day period in Sprague-Dawley rats. The results indicated that high doses of L-SeMc caused significant adverse effects, including howling, hair loss, lethargy, and poor locomotor ability, leading to the euthanization of six female rats. Other selenium supplements did not show significant abnormalities in clinical observations and eye examinations. The study provides a basis for assessing the safety and clinical application of these selenium supplements.
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