Systemic Subchronic Toxicity and Comparison of Four Selenium Nutritional Supplements by 90-Day Oral Exposure in Sprague-Dawley Rats

    September 2023 in “ Food and chemical toxicology ”
    Lamei Yu, Yanmei Li, Wen Qu, Yanhua Zheng, Xuejiao Chen, Su Fu, Jingjing Qu, Jie Tian, Shuiyuan Cheng, Xin Cong, Bolin Fan, Chunhong Wang
    Image of study
    TLDR High doses of some selenium supplements caused liver and reproductive harm in rats.
    The study investigated the systemic subchronic toxicity of four selenium nutritional supplements (SeP, SeY, L-SeMc, and Na2SeO3) over a 90-day period in Sprague-Dawley rats. The results indicated that high doses of L-SeMc caused significant adverse effects, including howling, hair loss, lethargy, and poor locomotor ability, leading to the euthanization of six female rats. Other selenium supplements did not show significant abnormalities in clinical observations and eye examinations. The study provides a basis for assessing the safety and clinical application of these selenium supplements.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 114 results

      community I feel like people here shrug off nutritional issues too quickly. Particularly for Retrograde Alopecia.

      in Chat  10 upvotes 2 years ago
      The user believes Retrograde Alopecia may be linked to vitamin imbalances, specifically from taking too much Vitamin E, A, Zinc, and Selenium, and suggests it could be a middle ground between Androgenic Alopecia and Telogen Effluvium. Treatments for hair loss mentioned include Androgen inhibitors and improving lifestyle factors like nutrition and sleep, with topical melatonin also recommended for Retrograde Alopecia.

      community 3 Mo Progress Fin/Min- Sept.-Dec

      in Is this regrowth?  22 upvotes 3 months ago
      The conversation is about a user sharing their positive progress with hair regrowth using oral minoxidil, biotin, finasteride, and other supplements. The user also mentions using a HIMS oral fin/min combo and receives advice and encouragement from others.

      community Shedding and thinning won’t stop on Nuclear protocol

      in Treatment  21 upvotes 1 year ago
      The user is using a combination of hair loss treatments including dutasteride, minoxidil, RU58841, low-level laser therapy, ketokonozole, supplements, Viviscal, Nutrafol, microneedling, PRP, and scalp Botox injections, but is still experiencing hair shedding and thinning. Despite being on this regimen for two years, the user's hair condition is worsening, and they are seeking advice on what else they can do.

      community Rate my treatment stack from 1-10

      in Chat 4 months ago
      The conversation discusses various hair loss treatments, with a focus on pyrilutamide, minoxidil, and alternatives to finasteride due to intolerance. Users suggest adding a DHT blocker like finasteride or dutasteride, and some recommend trying topical versions to reduce side effects.

    Similar Research

    5 / 740 results