Effects of High-Dose Radioactive Iodine Therapy on Hormonal Profiles and Sperm Quality in Thyroidectomy Patients

    February 2026 in “ Molecular Imaging and Radionuclide Therapy ”
    Mehrsadat Alavi, Raziyeh Hojjat, Ali Taghinezhad, Manzarbanoo Shojaeifard
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    TLDR High-dose radioactive iodine therapy does not harm fertility in thyroidectomy patients.
    A study on male patients who received 150 mCi of radioactive iodine therapy (RIT) after thyroidectomy found no impairment in fertility. However, the authors emphasize the need for long-term follow-up studies with larger sample sizes to better understand the physiological roles of gonadal hormones, sperm DNA fragmentation, and anti-Müllerian hormone (AMH) in the testes following RIT.
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