The Effect of 5-Alpha Reductase Inhibitor on Male Reproductive Function

    February 2024 in “ The Journal of Sexual Medicine ”
    Seung-Hun Song, Tae Hoon Lee, Kim Ds
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    TLDR 5-α reductase inhibitors do not significantly affect male reproductive function but may reduce semen volume.
    The study investigated the effect of 5-α reductase inhibitor (5-ARI), such as finasteride or dutasteride, on male reproductive function. The study included 40 healthy males of reproductive age who were taking 5-ARI for androgenic alopecia and compared them to a control group of 48 males not taking any medication. The results showed no significant difference in erectile function, semen parameters such as sperm concentration, motility, progressive motility, and morphology between the two groups. However, the semen volume was smaller in the 5-ARI group. Serum testosterone and FSH were higher in the 5-ARI group. The study concluded that 5-ARI does not significantly affect male reproductive function, but a cautious approach is recommended for men with oligospermia or ejaculatory dysfunction.
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