Steady-State Pharmacokinetics of Oral Testosterone Undecanoate with Concomitant Inhibition of 5α-Reductase by Finasteride

    October 2010 in “ International Journal of Andrology ”
    Markus Roth, Robert E Dudley, Lisa Hull, Andrew Y. T. Leung, Peter D. Christenson, C. H. Wang, Ronald S. Swerdloff, John K. Amory
    Image of study
    TLDR Finasteride doesn't affect oral testosterone undecanoate, and high DHT levels may cause acne, prostate issues, and hair loss.
    This study investigated the effects of finasteride, a 5α-reductase inhibitor, on the pharmacokinetics of oral testosterone undecanoate (TU). The study found that finasteride was unable to suppress serum dihydrotestosterone (DHT) and increase serum testosterone after the oral administration of TU as compared with other tested formulations of oral testosterone. This may be due to the variable methods of absorption between these two oral formulations. The study also found that oral dosing of TU is associated with supraphysiological elevations in serum DHT, which may increase the risk of DHT-related conditions such as acne, benign prostatic hypertrophy, and androgenic alopecia.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 1000+ results

      community NW5 at 19. How many grafts do I need?

      in Transplants  138 upvotes 2 years ago
      A 19-year-old with rapid hair loss since 16 is considering a hair transplant but refuses to take finasteride or any 5α-Reductase inhibitors. They are currently using minoxidil, tretinoin, and microneedling with a Derminator 2, and only want hair until age 27.

      community Finasteride does deplete important nuero-active steroids

      in Research/Science  9 upvotes 2 years ago
      Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

      community Another clueless guy fearmongering and spreading misinformation

      in Chat  251 upvotes 2 years ago
      The conversation discusses hair loss treatments, with some users advocating for finasteride and minoxidil, while others express concerns about potential side effects of finasteride. A social media influencer is criticized for promoting scalp massages and minoxidil over finasteride, which some believe is misinformation.

    Related Research

    1 / 1 results