Clinical Corner: Case Report on Spermatozoa and Chronic Treatment with Finasteride: A TEM and FISH Study

January 2007

Giulia Collodel, Elena Moretti

finasteride Transmission Electron Microscopy Fluorescence In Situ Hybridization spermatozoa benign prostatic hyperplasia Propecia TEM FISH

Studysummary In this study, three cases of young men using finasteride for five years showed altered sperm morphology and motility issues, with partial improvement observed after discontinuation.

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Research cited in this study

4 / 4 results

research Finasteride-Associated Male Infertility

34 citations , January 2004 in “Revista do Hospital das Clínicas”

The authors reported that young men with infertility-related conditions experienced improved seminal quality after stopping finasteride, suggesting potential adverse effects on fertility during treatment.

research Suppression of Spermatogenesis with Desogestrel and Testosterone Pellets Is Not Enhanced by Addition of Finasteride

31 citations , January 2001 in “PubMed”

In this randomized study of male contraceptive regimens, adding finasteride did not significantly enhance spermatogenesis suppression compared to the control group.

research Chronic Treatment with Finasteride Daily Does Not Affect Spermatogenesis or Semen Production in Young Men

104 citations , October 1999 in “The Journal of Urology”

This study concluded that daily treatment with 1 mg finasteride did not affect spermatogenesis or semen production in young men and had small, reversible effects on prostate volume and serum PSA.

research Decreased Fertility in Male Rats Administered the 5α-Reductase Inhibitor, Finasteride, Due to Deficits in Copulatory Plug Formation

37 citations , January 1991 in “Reproductive Toxicology”

The study observed that finasteride reduced fertility in male Sprague-Dawley rats by impairing the formation of copulatory plugs, an effect considered specific to rats and not applicable to species without this reproductive feature.