January 2007 in “Chinese Journal of Analysis Laboratory” This study proposed a method to determine residual levels of dichloromethane and chloroform in finasteride using SPME-GC, reporting high linear correlation coefficients for both solvents.
56 citations
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January 1996 in “Journal of Forensic Sciences” This study found that rhodamine B penetrated human hair fibers more effectively from an aqueous solution compared to a methanol/ethanol solvent, with penetration depending on hair morphology.
20 citations
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October 2018 in “Physics and chemistry of liquids” This study found that minoxidil exhibits preferential solvation by water in both water-rich and ethanol-rich solvent mixtures.
2 citations
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November 2021 in “International Journal of Applied Pharmaceutics” This study found that a phytosome lotion made from Mangkokan leaf extract, using a green solvent and microwave-assisted extraction, demonstrated greater hair growth activity than 2% minoxidil, with the 30% phytosome lotion showing the highest efficacy in increasing hair length, weight, and diameter.
1 citations
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January 2007 in “Heterocyclic Communications” This study reports a new method for selectively synthesizing finasteride Form-I in good yield using water as an ecofriendly solvent at room temperature.
July 2026 in “Journal of Investigative Dermatology” This study in mice found that using modified illite as a carrier for topical minoxidil enabled effective delivery without the solvent toxicity typically associated with minoxidil, while the illite also promoted hair growth through anti-inflammatory and pro-proliferative mechanisms.
December 2022 in “Ecological Chemistry and Engineering S” This study synthesized indole-acenaphthylene compounds using a magnetic nanocatalyst and explored their photoluminescence properties for detecting copper ions in a mixed solvent system, achieving a detection limit of 9.5 ∙ 10 –6 M.
January 2013 in “วารสารเภสัชศาสตร์อีสาน (Isan Journal of Pharmaceutical Sciences, IJPS)” This study found that ethyl acetate extract from mangosteen pericarp exhibited the strongest antibacterial effect against Propionibacterium acnes compared to other extraction solvents.
14 citations
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April 2018 in “ACS Biomaterials Science & Engineering” In this study, luteolin-loaded nanoemulsions were shown to promote hair growth similarly to a luteolin solution in organic solvents, offering enhanced stability for follicular delivery.
11 citations
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January 2006 in “Drug development and industrial pharmacy” In this study, adding TPGS to a minoxidil formulation improved local retention and reduced systemic absorption in certain solvent mixes, particularly with a balance of alcohol and PEG 400.
10 citations
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May 1978 in “Acta Dermato Venereologica” In this study, seven patients with generalized toxic erythema developed sterile pustules localized to hair follicles or sweat ducts, with most having a history of medication, solvent exposure, or infection.
3 citations
,
October 2014 in “Pharmaceutical Development and Technology” This study found that an optimized microemulsion for minoxidil with high solubility, permeation flux, and skin deposition can be achieved with specific low and high levels of certain surfactants and co-solvents.
December 2025 in “Pharmaceuticals” This study found that a natural illite-based carrier could deliver minoxidil topically with preserved efficacy, minimizing solvent toxicity, and showed hair-growth-promoting activity via anti-inflammatory and pro-proliferative mechanisms in mice.
November 2025 in “Molecules” This review examines recent advancements in green and emerging microextraction techniques, such as SPME and DLLME, for more sustainable hormone detection in biological samples, emphasizing environmentally friendly solvents and bioanalytical applications.
April 2025 in “The Journal of Agriculture and Development” In this study, researchers optimized the extraction conditions for polyphenols from the medicinal herb Eclipta prostrata, achieving the highest polyphenol content under specific conditions of temperature, solvent concentration, and time, and found the extract to have significant antioxidant activity.
October 2023 in “Journal of Molecular Liquids” This study demonstrated that imidazole-based ionic liquids, particularly [Emim]DEP, effectively dissolved yak hair keratin, maintaining its structure better than other tested solvents, and also performed well on human hair and goat wool, with consistent performance even after five recycling cycles.
April 2022 in “Molecules” This study identified two potent 5α-reductase inhibitors from Tectona grandis leaves, and suggests that ethanol is a preferable solvent for extracting these compounds, which are potential ingredients for hair loss treatments.
7 citations
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August 2020 in “Majalah Farmasetika” This review concluded that a herbal hair tonic formulated with 2.5% green tea leaf extract, in combination with specific solvents and additives, showed the best properties for stimulating hair growth.
2 citations
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February 2021 in “IOP Conference Series Earth and Environmental Science” This study identified that Mangkokan leaf extracts contain active compounds such as alkaloids, flavonoids, steroids, tannins, phenols, and saponins, using different solvents and FTIR analysis.
May 2024 in “Research Journal of Pharmacy and Technology” This study introduced new spectrophotometric methods to estimate Minoxidil in pharmaceutical forms, demonstrating its linearity across various buffers and solvents, and found these methods to be simple, economical, and effective according to ICH guidelines.
July 2026 in “Journal of Medicinal Plants Studies” In this study, methanolic extracts of Hibiscus rosa-sinensis showed higher phenolic and flavonoid content, as well as greater concentrations of gallic acid and quercetin, than aqueous extracts, despite the latter yielding more extract, highlighting the effectiveness of methanol for extracting bioactive phytochemicals.
52 citations
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January 2005 in “International journal of experimental pathology” This study suggests that melatonin may have a radioprotective role against X-ray-induced skin damage in rats, as evidenced by milder injury markers in pretreated animals.
23 citations
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March 2019 in “Journal of Essential Oil Research” This study found a strong correlation between antioxidant activity and phenolic content in rosemary, influenced by bioclimatic and seasonal factors in different stages of Tunisia.
19 citations
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March 1961 in “Nature” A fatty acid/protein complex in human hair helps protect it from damage.
7 citations
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July 2015 in “Parasitology Research” This study found that the imidacloprid/flumethrin collar (Seresto®) is chemically compatible with major spot-on formulations and dermally and systemically safe for adult dogs and cats when used together.
3 citations
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December 2024 in “Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512)” This study reported that meloxicam-loaded spanlastics, created using the ethanol injection method, demonstrated potential as a drug delivery system with sustained release and effective entrapment efficiency.
2 citations
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July 2019 in “IOP conference series. Materials science and engineering” This study found that under optimized extraction conditions, the Gleditschia fera fruit extract contained a high level of saponins and demonstrated notable antioxidant activity.
2 citations
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October 2018 in “Journal of Mind and Medical Sciences” This study developed a straightforward HPTLC method for detecting nicotine and cotinine in human plasma and urine, concluding that liquid-liquid extraction with methanol: chloroform: ammonia achieved optimal separation and is applicable for forensic analysis of lethal nicotine intoxication.
1 citations
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December 2022 in “International Journal of Science for Global Sustainability” This study found that Mitracarpus hirtus extracts showed potential antifungal activity against Tinea capitis in vitro, with ethylacetate extracts demonstrating the highest inhibitory effects.
1 citations
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January 2017 in “Chinese Journal of Organic Chemistry” Using K2S2O8 as an oxidizing agent in a specific condition, we can make Finasteride with 96.3% yield and 99.6% purity. This method is also good for other compounds and is environmentally friendly.