Chemical Compatibility and Safety of Imidacloprid/Flumethrin Collar (Seresto) Concomitantly Used with Imidacloprid/Moxidectin (Advocate, Advantage Multi) and Emodepside/Praziquantel (Profender) Spot-on Formulations

A series of studies evaluated the chemical compatibility and safety of the imidacloprid/flumethrin collar (Seresto®) when used with spot-on or tablet formulations in cats and dogs. In-vitro tests showed that certain solvents affected the collar, but not in marketed formulations. Clinical studies, both controlled and non-controlled, assessed dermal and systemic safety, revealing only transient cosmetic changes and minor skin alterations at application sites, with no significant systemic safety issues. Blood parameter deviations were noted but deemed clinically irrelevant. Overall, Seresto® was found to be chemically compatible and safe for concurrent use with Advocate® and Profender® formulations in adult dogs and cats.