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Glossary Solid Lipid Nanoparticles

tiny particles made from fats to deliver drugs effectively

Solid Lipid Nanoparticles (SLNs) are tiny particles made from solid lipids that are used to deliver drugs, vitamins, or other active ingredients in a controlled manner. They are advantageous because they can improve the stability and bioavailability of the substances they carry, making them more effective. SLNs are particularly useful in medical and cosmetic applications, including treatments for hair loss and skin conditions.

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Development, Formulation, and Characterization of an Adapalene-Loaded Solid Lipid Microparticle Dispersion for Follicular Penetration

research Development, formulation, and characterization of an adapalene-loaded solid lipid microparticle dispersion for follicular penetration

26 citations , March 2014 in “International journal of pharmaceutics”

This study confirmed that the novel solid lipid microparticle formulation of adapalene demonstrated follicular penetration potential and targeted particle erosion in sebum in in vitro tests.

research Lidocaine-Loaded Solid Lipid Microparticles (SLMPs) Produced from Gas-Saturated Solutions for Wound Applications

24 citations , September 2020 in “Pharmaceutics”

In this study, solid lipid microparticles loaded with lidocaine hydrochloride were developed to effectively deliver pain relief and antimicrobial benefits for wound management, demonstrated by testing with bioengineered skin substitutes and showing effectiveness against common wound-infecting bacteria.

research Incorporation of benzoyl peroxide nanocrystals into adapalene-loaded solid lipid microparticles: Part II – Solid-in-Oil dispersion of nanoparticulate benzoyl peroxide

8 citations , November 2019 in “International Journal of Pharmaceutics”

This work explores using a liquid crystalline phase to stabilize benzoyl peroxide nanosuspensions, suggesting a promising method to potentially reduce the side effects of acne treatments.

research Development of Effervescent Cleansing Tablets Containing Asiatic-Acid-Loaded Solid Lipid Microparticles

3 citations , October 2023 in “Cosmetics”

This study developed effervescent cleansing tablets containing asiatic-acid-loaded solid lipid microparticles, finding that they provided effective cleansing compared to water and showed good flow properties, pH, and hardness but were unstable at high temperature and humidity.

research Ex-Vivo Evaluation of Eflornitine Hydrochloride Loaded Solid Lipid Microparticles Based Cream

November 2021 in “SPAST Abstracts”

In this study, EFH-SLM cream demonstrated greater efficiency in reducing hair density compared to plain EFH cream in Swiss albino female mice, with significantly less skin irritation and inflammation observed, suggesting improved permeability and effectiveness of EFH when using the new cream formulation.

Comparison of Rheological Properties, Follicular Penetration, Drug Release, and Permeation Behavior of a Novel Topical Drug Delivery System and a Conventional Cream

research Comparison of rheological properties, follicular penetration, drug release, and permeation behavior of a novel topical drug delivery system and a conventional cream

34 citations , October 2014 in “European journal of pharmaceutics and biopharmaceutics”

This study found that adapalene-loaded solid lipid microparticles may enhance targeted drug delivery into sebum due to their similarity to sebum components, although both this formulation and a standard cream showed equivalent follicular penetration.

research Solid lipid nanoparticles suspension versus commercial solutions for dermal delivery of minoxidil

26 citations , June 2011 in “International Journal of Pharmaceutics”

This study found that solid lipid nanoparticles with minoxidil were as effective as commercial solutions for skin penetration and were non-corrosive, indicating potential for hair loss treatment.

research Solid Lipid Nanoparticles for Drug Delivery: Pharmacological and Biopharmaceutical Aspects

559 citations , October 2020 in “Frontiers in Molecular Biosciences”

This review reports on the current state and potential of solid lipid nanoparticles for drug delivery, emphasizing their safety, biocompatibility, and ease of production, and highlights challenges in translating them to clinical practice, including active clinical trials.

research Roxithromycin-loaded lipid nanoparticles for follicular targeting

35 citations , October 2015 in “International Journal of Pharmaceutics”

Tiny particles carrying roxithromycin can effectively target and deliver the drug to hair follicles without irritation.

research Physicochemical Characterization of Chitosan-Decorated Finasteride Solid Lipid Nanoparticles for Skin Drug Delivery

1 citations , January 2022 in “BioMed Research International”

This study reported that solid lipid nanoparticles of finasteride decorated with chitosan enhanced drug retention in skin layers, suggesting potential application in treating androgenic alopecia and benign prostate hyperplasia with fewer side effects.

research Applications and limitations of lipid nanoparticles in dermal and transdermal drug delivery via the follicular route

95 citations , July 2015 in “European journal of pharmaceutics and biopharmaceutics”

This review discusses the application of lipid nanoparticles for enhancing drug delivery through hair follicles and reports no new clinical results, emphasizing the potential role of sebum-like lipids in this context.

research Lipid Nanoparticles Based Cosmetics with Potential Application in Alleviating Skin Disorders

59 citations , September 2021 in “Cosmetics”

This review discusses lipid nanoparticle-based cosmetics, emphasizing their potential in protecting skin from radiation and treating conditions like atopic dermatitis and psoriasis with synthetic and natural antioxidants. It highlights recent research on these formulations' effectiveness in alleviating skin disorders and enhancing skin health.

research Lipid nanocosmeceuticals: a novel approach to skin therapy for anti-aging and skin disorders

1 citations , October 2025 in “Beni-Suef University Journal of Basic and Applied Sciences”

This study reviews lipid-based nanocosmeceuticals and reports that they enhance therapeutic effectiveness in dermatological applications by improving skin hydration, reducing wrinkles, and effectively managing conditions like psoriasis and eczema, though further large-scale trials and regulatory alignment are needed for clinical use.

research V Congress of the Portuguese Society of Cosmetological Sciences - Proceedings

June 2015 in “Biomedical and biopharmaceutical research”

This article reviews EU cosmetic product claim regulations and highlights increased harmonization and enforcement while reporting no new results.

II Nanosciences and Nanotechnology Biomedicals Symposium - Proceedings

research II Nanosciesce and Nanotecnology Biomedicals Symposium - Proceedings

December 2013 in “Biomedical and biopharmaceutical research”

This review discusses technological advances in liposome systems for drug delivery and reports no new clinical results; it highlights the clinical acceptance and market presence of liposomal products.

research Nanocarrier Systems for Transdermal Drug Delivery

13 citations , October 2012 in “InTech eBooks”

Nanocarriers could improve how drugs are delivered through the skin but require more research to overcome challenges and ensure safety.

research Recent Advances in the Structural Design of Photosensitive Agent Formulations Using “Soft” Colloidal Nanocarriers

54 citations , June 2020 in “Pharmaceutics”

This review discusses the advancements in using "soft" colloidal nanocarriers for delivering photosensitive agents and highlights their potential applications in treating diseases like cancer, but it reports no new clinical results.

research A novel microparticle based formulation for topical delivery of FOL-005, a small peptide

1 citations , January 2022 in “Journal of Pharmaceutical Sciences”

This study developed a stable, cosmetically appealing formulation for the topical delivery of the peptide FOL-005, enhancing skin permeation and maintaining stability by keeping the peptide solid and in a water-free environment with particle sizes under 10 µm.

Investigation of the Cutaneous Penetration Behavior of Dexamethasone Loaded to Nano-Sized Lipid Particles by EPR Spectroscopy, and Confocal Raman and Laser Scanning Microscopy

research Investigation of the cutaneous penetration behavior of dexamethasone loaded to nano-sized lipid particles by EPR spectroscopy, and confocal Raman and laser scanning microscopy

21 citations , December 2016 in “European journal of pharmaceutics and biopharmaceutics”

This study found that nano-sized lipid particles improved the skin accumulation and retention of dexamethasone compared to a base cream, suggesting potential benefits for inflammatory skin disease treatment.

research Follicular delivery of spironolactone via nanostructured lipid carriers for management of alopecia

89 citations , November 2014 in “International Journal of Nanomedicine”

This study suggests that spironolactone-loaded nanostructured lipid carriers could enhance follicular delivery and offer a more localized treatment for androgenic alopecia, potentially reducing systemic side effects.

research Nanoporous Silica Entrapped Lipid-Drug Complexes for the Solubilization and Absorption Enhancement of Poorly Soluble Drugs

8 citations , January 2021 in “Pharmaceutics”

This study found that using nanoporous silica entrapped lipid-drug complexes enhanced the solubility and bioavailability of dutasteride in beagle dogs.

research Preparation and in vivo evaluation of lecithin-based microparticles for topical delivery of minoxidil

12 citations , August 2017 in “Archives of Pharmacal Research”

In this study, lecithin-based microparticle formulations of minoxidil showed enhanced skin penetration and comparable hair growth effectiveness to commercial products in mice, while minimizing skin irritation often seen with standard minoxidil solutions.

The Impact of Particle Size of Nanostructured Lipid Carriers on Follicular Drug Delivery: A Comprehensive Analysis of Mouse and Human Hair Follicle Penetration

research The impact of particle size of nanostructured lipid carriers on follicular drug delivery: A comprehensive analysis of mouse and human hair follicle penetration

March 2024 in “Bioimpacts”

In this study, curcumin-loaded nanoparticles with a size of 400 nm showed optimal accumulation in human hair follicles after seven days, although mouse models differed significantly in penetration and retention, indicating limitations in their suitability for follicular drug delivery studies.

Green Formulation of Spironolactone Loaded Chitosan Coated Nano Lipid Carrier for Treatment of Acne Vulgaris: A Randomized Double-Blind Clinical Trial

research Green formulation of spironolactone loaded chitosan coated nano lipid carrier for treatment of acne vulgaris: a randomized double-blind clinical trial

8 citations , September 2023 in “Advanced Pharmaceutical Bulletin”

In a double-blind clinical trial, this study found that a gel containing chitosan-coated spironolactone nanoparticles effectively reduced acne lesions over 8 weeks without adverse skin effects, suggesting potential for enhanced acne treatment through targeted skin delivery.

research Effect of physical stimuli on hair follicle deposition of clobetasol-loaded Lipid Nanocarriers

52 citations , January 2020 in “Scientific Reports”

This study found that nanostructured lipid carriers with clobetasol propionate significantly enhance follicular drug delivery compared to commercial cream, and manual massage further doubles follicular retention.

research Chitosan microparticles for sustaining the topical delivery of minoxidil sulphate

45 citations , August 2011 in “Journal of Microencapsulation”

This study found that chitosan microparticles containing minoxidil sulphate sustained its release and may hold potential for targeted topical treatment of alopecia.

research Squarticles as a Lipid Nanocarrier for Delivering Diphencyprone and Minoxidil to Hair Follicles and Human Dermal Papilla Cells

62 citations , December 2013 in “Aaps Journal”

This research reported that squarticles, nanoparticles made from sebum-derived lipids, enhanced the follicular delivery and skin accumulation of diphencyprone and minoxidil, indicating effective drug deposition with reduced systemic absorption in alopecia treatment.

Topical And Transdermal Lipid-Polymer Hybrid Nanoparticles: An Integration In Advancing Dermatological Treatments

research Topical and transdermal lipid-polymer hybrid nanoparticles (LPN): an integration in advancing dermatological treatments

5 citations , August 2025 in “Drug Delivery and Translational Research”

This review discusses lipid-polymer hybrid nanoparticles for dermatological applications, outlining their structural and formulation advancements, but reports no new clinical results and calls for further research on their therapeutic potential.

research Focus on Skin as a Possible Port of Entry for Solid Nanoparticles and the Toxicological Impact

62 citations , October 2010 in “Journal of biomedical nanotechnology”

This review discusses the challenges and contradictions in understanding nanoparticle penetration and toxicity in human skin, emphasizing the need for standardized testing and further research on particles smaller than 10 nm.

research Follicular transport route – Research progress and future perspectives

211 citations , February 2009 in “European journal of pharmaceutics and biopharmaceutics”

This review summarizes recent advancements in follicular targeting for drug delivery via hair follicles and calls for pilot studies in humans to explore potential clinical applications.