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Glossary Solid-Phase Extraction

method to isolate specific compounds from a mixture

Solid-Phase Extraction (SPE) is a method used in laboratories to separate and concentrate specific compounds from a mixture. It involves passing a liquid sample through a solid material (the "solid phase") that selectively adsorbs the target compounds, allowing impurities to be washed away. This technique is widely used in fields like environmental testing, pharmaceuticals, and biochemistry for sample preparation and purification.

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Research

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research Selective and rapid determination of tadalafil and finasteride using solid phase extraction by high performance liquid chromatography and tandem mass spectrometry

9 citations , February 2018 in “Journal of Pharmaceutical and Biomedical Analysis”

This study validated a highly selective and fast LC–MS/MS method for accurately measuring levels of tadalafil and finasteride in human plasma, adhering to international bioanalytical guidelines.

research Caffeine in Hair Care and Anticellulite Cosmetics: Sample Preparation, Solid-Phase Extraction, and HPLC Determination.

December 2020 in “Journal of Cosmetic Science”

This study determined that caffeine content in anticellulite gels was between 0.7% and 1.7%, and about 1.0% in hair-care products.

research Targeted Determination of Residual Sex Hormones in Cosmetics Using Magnetic Solid-Phase Extraction with Isotope-Labeled Internal Standards by UHPLC-MS/MS

December 2025 in “Molecules”

This study developed a method using UHPLC-MS/MS and MSPE to detect trace amounts of sex hormones in cosmetics, finding progestins and estrogens in some products, and performed a preliminary safety evaluation for residual progesterone in hair loss prevention cosmetics.

research Analysis of hormone antagonists in clinical and municipal wastewater by isotopic dilution liquid chromatography tandem mass spectrometry

51 citations , February 2010 in “Analytical and Bioanalytical Chemistry”

Researchers developed a method to detect hormone-blocking drugs in wastewater and found them in Beijing's sewage, suggesting they can survive sewage treatment.

research Rapid and Sensitive LC–MS–MS Method for the Simultaneous Estimation of Alfuzosin and Dutasteride in Human Plasma

25 citations , October 2008 in “Chromatographia”

This study developed and validated a sensitive and rapid method to simultaneously measure alfuzosin and dutasteride in human plasma, enabling high-throughput analysis for pharmacokinetic and bioequivalence studies.

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Community Join

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community Did My Hair Transplant Fail????

11 upvotes 1 month ago

The user is concerned their hair transplant with 1500 grafts may have failed after 10 months, despite using 5% topical minoxidil and 1mg oral finasteride since 2023. Others suggest waiting until 18 months for full results and considering additional treatments like PRP or dutasteride.

community 2000 beard graft extracted with no visible scar

213 upvotes 1 year ago

A user shared their experience with a beard-to-scalp hair transplant, noting no visible scars and improved hair density using finasteride and minoxidil. The conversation discusses the differences between beard and scalp hair, potential changes in hair texture, and the use of beard hair for increased scalp coverage.

community 7 day hair transplant update - HLC Ankara - How we looking?

163 upvotes 7 months ago

A 35-year-old shared a 7-day update on their hair transplant, which involved 3,153 grafts performed by Dr. Elif at HLC Ankara, costing 10,000 euros including accommodations. The user has been on finasteride for over 12 years and opted for a partial shave FUE to address hairline recession and temple peaks.

community 3200 Grafts Medblue Turkey FUE + DHI - Dr. Turan (2800 FUE + 400 DHI + 9 months of updates)

542 upvotes 1 year ago

A person had a successful hair transplant in Turkey with 3200 grafts using FUE and DHI techniques, and is satisfied with the results after 9 months. They have been using finasteride for 7 years to maintain hair health.

community My experience with Harmony Clinic in Cancun, MX

39 upvotes 4 years ago

A user had a positive experience with affordable FUE hair transplants at Harmony Clinic in Cancun, Mexico, noting professionalism and good results despite minor issues. The clinic advised against using Minoxidil and Finasteride, and the user was satisfied with the initial results, planning to update progress at 12 months post-op.

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Learn

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learn GT20029

When will GT20029 be commercially available, and are there any clinical trials on its use? GT20029 is investigational and not approved or sold anywhere. A published 12-week Phase II study in 180 Chinese men reports hair-count gains over placebo with two of four regimens, but no long-term or Phase III data exists, so any launch is years away at best.

learn TDM-105795

How is TDM-105795 used in hair-related products, and is it being explored as a topical treatment, an oral option, or both? TDM-105795 is not sold in any hair product — it is an unapproved experimental compound. The public trial registry shows it has been studied only as a topical scalp solution, in three completed company trials (the largest a 71-participant, 16-week Phase 2); no oral programme is registered, and no peer-reviewed publication exists.

learn Fluridil

Topical anti-androgen sold as a cosmetic lotion

learn RU58841

Experimental topical anti-androgen sold as a research chemical

learn Exosomes

What does Fluridil do on the scalp, and how does it block the DHT hormone? Fluridil is a topical anti-androgen sold in some European countries. One small 2002 trial led by its developer reported more hairs in the growth phase; it is not FDA-approved and the evidence is limited.

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Clinics

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Hair Systems
Mane PhaseRancho Cucamonga, CA · US

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