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    GlossaryElectron Paramagnetic Resonance Spectroscopy

    measures unpaired electrons' behavior in magnetic fields

    Electron Paramagnetic Resonance (EPR) Spectroscopy, also known as Electron Spin Resonance (ESR) Spectroscopy, is a technique used to study materials with unpaired electrons. It works by applying a magnetic field to a sample and measuring the resonant absorption of microwave radiation, which provides detailed information about the electronic structure and local environment of the paramagnetic species. This method is particularly useful in fields like chemistry, biology, and materials science for investigating free radicals, transition metal complexes, and defects in solids.

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      community The mechanism of androgenic alopecia

      in Research/Science  31 upvotes 2 days ago
      DHT may inhibit hair growth by affecting mitochondrial function, leading to hair follicle miniaturization. Treatments like minoxidil and PP405 may promote hair growth by altering metabolic pathways, potentially counteracting DHT's effects.

      community Possible natural pp405 solution

      in Research/Science  45 upvotes 1 month ago
      Rotenone, a natural plant extract, may promote hair growth by increasing LDH activity and blocking MPC in the scalp, but it carries risks due to its toxicity. The suggested formulation includes Barbasco extract, DMSO, propylene glycol or PEG-400, ethanol, and a carrier oil.

      community Verteporfin and Microneedling

      in Treatments 1 year ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.