Ex-Vivo Evaluation of Eflornithine Hydrochloride Loaded Solid Lipid Microparticles Based Cream
November 2021
in “
SPAST Abstracts
”
Studysummary In this study, EFH-SLM cream demonstrated greater efficiency in reducing hair density compared to plain EFH cream in Swiss albino female mice, with significantly less skin irritation and inflammation observed, suggesting improved permeability and effectiveness of EFH when using the new cream formulation.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The study evaluated the effectiveness of a cream containing eflornithine hydrochloride loaded solid lipid microparticles (EFH-SLM) for treating hirsutism, a condition characterized by excessive hair growth in women. The research involved ex-vivo hair regrowth studies on healthy Swiss albino female mice. Results showed that the EFH-SLM cream was more effective than plain EFH cream, as it resulted in modest hair density and greater hair weight per cm² by day 21. The enhanced performance was attributed to the greater permeability of EFH from the EFH-SLM formulation. Additionally, the EFH-SLM cream caused fewer skin rashes and less inflammation compared to the plain EFH cream and marketed EFH cream, suggesting it as a preferable treatment option for hirsutism.
