Targeting Pharmacological and Nanotechnology Based Therapeutics for Management of Hirsutism: A Comprehensive State-of-the-Art

    December 2023 in “ ̒Ulūm-i dārūyī
    Ishrat Zahoor, Sukhbir S. Singh, Neelam Sharma, Ikmeet Kaur Grewal, Shahid Nazir Wani
    TLDR New treatments for excessive hair growth in women, including advanced drugs and nanotechnology, show promise for better results.
    Hirsutism, characterized by excessive coarse hair growth in women, affects 5 to 10% of females of reproductive age and is often caused by an overabundance of androgens secreted by the ovaries or adrenal glands. Various causes include polycystic ovarian syndrome, Cushing syndrome, insulin resistance, congenital adrenal hyperplasia, ovarian or adrenal tumors, menopause, and certain drugs. Polycystic ovary syndrome and ovarian tumors are common causes of hyperandrogenism, leading to hirsutism. Treatments include oral contraceptives, antiandrogen therapy (spironolactone, cyproterone acetate, flutamide, finasteride), insulin-lowering medicines, gonadotrophin-releasing hormone agonists, and topical treatment such as eflornithine hydrochloride cream. The review also highlights the role of nanotechnology-based methods like nanostructured lipid carriers, solid lipid nanoparticles, liposomes, cerosomes, and nanogel in enhancing the effectiveness of hirsutism medications.
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