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This study developed mouse models to better understand acquired skin appendage dysfunction, finding that ultra-thin skin grafts maintained stable areas with minimal hair follicles compared to controls, which aids research on skin regeneration therapies.

This review explores the emerging role of postbiotics—such as inactivated bacteria, cell components, and metabolites—in enhancing wound healing and skin microbiome health, highlighting evidence from various preclinical and preliminary clinical studies.

This study identified a crucial Gli2-Serpinh1 regulatory axis that regulates fibroblast state transitions during skin wound healing, shedding light on fibroblast heterogeneity and suggesting potential precision regenerative therapies.

This study found that SPARC-overexpressing adipose-derived mesenchymal stem cells significantly improved various aspects of skin wound healing in dogs, including re-epithelialization, collagen deposition, and angiogenesis, showing promise for enhancing treatment effectiveness under different physiological and pathological conditions.

Skin organoids can mimic human skin responses to injury and inflammation, making them useful for studying skin diseases and testing treatments.

Stem cell therapies show promise for healing skin wounds but need more testing.

In this study, researchers developed an axolotl skin-derived extracellular matrix scaffold that enhanced wound healing in mice by promoting skin regeneration and reducing fibrosis, offering potential as a regenerative biomaterial for clinical use.

In this study, a silk fibroin hydrogel containing recombinant NT3 was found to promote scar-less wound healing in a mouse skin injury model by enhancing type III collagen expression and inducing hair follicle formation.

This study found that the CD301b-expressing subpopulation of macrophages plays a crucial role in promoting reparative processes during the mid-stage of skin wound healing in a mouse model.

In this study, Msx-2 knockout mice showed enhanced re-epithelialization and faster wound closure compared to wild-type controls, suggesting Msx-2 may influence skin morphogenesis during wound repair.

This study found that MRL/MpJ mouse dorsal skin wounds heal with similar scar formation and collagen deposition as C57bl/6 and Balb/c mice.

This study found that dendritic epidermal T cells and their exosomes enhance epidermal stem cell proliferation, accelerating wound re-epithelialization in the skin.

This study found that fibroin/gelatin and spidroin microparticles increased re-epithelialization rates and inhibited scar formation in mouse models of deep skin wounds.

In this study, researchers using single nuclei RNA-sequencing found that fibroblasts in deeper layers of mouse skin expressed higher levels of pro-inflammatory genes post-wounding compared to other cells, highlighting their significant role in early inflammation and tissue repair processes.

This study found that sheep testis extract significantly improved wound healing and hair follicle growth in rats, suggesting it may be a promising candidate for clinical wound healing research.

This review explores how epithelial cells from various niches in the skin respond and adapt during acute wound repair, highlighting the role of cellular plasticity in reepithelialization and restoring the skin's barrier function.

The skin is essential for protection, temperature control, and immune defense.

Scalp-to-scalp skin grafts quickly heal and hide well under regrown hair, making them good for repairing large scalp defects.

In this study, researchers found that hair follicle stem cells activate an immune-modulatory program during wound healing, promoting Treg cell expansion and aiding skin repair, while deleting certain immune components impaired healing and increased inflammation in a mouse model.

This study found that incorporating human adipose subcutaneous tissue in 3D organotypic skin cultures mimicking hypertrophic scar conditions improved epidermal homeostasis, formed a basement membrane similar to native skin, and reduced myofibroblast presence, indicating an anti-fibrotic effect.

In this study, the combination of full-thickness skin column grafts and the TSN6 peptide improved wound healing quality in pigs by enhancing epidermal maturation compared to other treatments.

This study reports that a multifunctional artificial skin using photothermal-triggered drug delivery improved full-thickness wound healing and skin appendage regeneration by coordinating the release of several therapeutic agents.

This study found that hair follicle transplantation improved wound healing in diabetic mice by promoting tissue regeneration and reducing inflammation, with follicles from normoglycemic conditions proving more effective than those from hyperglycemic environments.

In this study, PRP significantly accelerated early wound healing in rabbits, with faster closure and improved tissue characteristics compared to controls, although both groups achieved near-complete healing by four weeks.

This study found that a new topical nitric oxide gel significantly accelerated burn wound healing in mice by enhancing re-epithelialization, hair follicle regeneration, collagen deposition, and angiogenesis compared to controls.

This study found that wounds in sheep treated with mesenchymal stem cells and platelet-rich plasma showed improved healing, reduced inflammation and contraction, and better skin structure compared to untreated wounds.

In this animal study, researchers found that nanofibers combining gold nanoparticles with silk fibroin improved wound healing more effectively than silk fibroin alone, promoting faster skin recovery and hair follicle formation in rats over 7 and 21 days.

The researchers reported that a 4-aminopyridine-loaded gel promoted wound healing and hair follicle regeneration in burn models, suggesting it might be a promising alternative to existing burn treatments.

Aloe vera extract helps heal burn wounds faster in rats.

Aloe vera may help heal burns by boosting skin cell growth.