Assessment of the Quality of the Healing Process in Experimentally Induced Skin Lesions Treated with Autologous Platelet Concentrate Associated or Unassociated with Allogeneic Mesenchymal Stem Cells: Preliminary Results in a Large Animal Model

This study assessed the healing quality of skin lesions in sheep using autologous platelet-rich plasma (PRP) alone or combined with mesenchymal stem cells (MSCs). Conducted on 3 sheep, the study found that both treatments improved wound healing compared to untreated wounds, with the combination of PRP and MSCs notably reducing inflammation and enhancing re-epithelialization. By 21 days, wounds treated with PRP and MSCs showed better organization of skin structures and increased granulation tissue. By 42 days, these wounds had a more organized structure and increased cell proliferation and angiogenesis. Despite the small sample size, the findings suggest that PRP combined with MSCs could be a promising therapy for improving wound healing.