Axolotl-Derived Decellularized Skin ECM as a Pro-Regenerative Scaffold for Attenuating Fibrotic Wound Healing

    October 2025 in “ Materials Today Bio ”
    Mu‐Hui Wang, Chen‐Hsiang Kuan, Hsu Ma, Nai‐Chen Cheng
    Studysummary In this study, researchers developed an axolotl skin-derived extracellular matrix scaffold that enhanced wound healing in mice by promoting skin regeneration and reducing fibrosis, offering potential as a regenerative biomaterial for clinical use.
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    Research cited in this study 9

    1. New Insights Into Balancing Wound Healing And Scarless Skin Repair Journal of Tissue Engineering · 2023
    2. Matrisomal Components Involved in Regenerative Wound Healing in Axolotl and Acomys: Implications for Biomaterial Development Biomaterials Science · 2023
    3. Activating an Adaptive Immune Response from a Hydrogel Scaffold Imparts Regenerative Wound Healing Nature Materials · 2020
    4. Comparative Proteomic Analysis in Scar-Free Skin Regeneration in Acomys Cahirinus and Scarring Mus Musculus Scientific Reports · 2020
    5. Regeneration of Dermis: Scarring and Cells Involved Cells · 2019
    6. Scarless Wound Healing: Transitioning from Fetal Research to Regenerative Healing Wiley Interdisciplinary Reviews-Developmental Biology · 2018
    7. Minimizing Skin Scarring Through Biomaterial Design Journal of Functional Biomaterials · 2017
    8. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    9. Skin Shedding and Tissue Regeneration in African Spiny Mice (Acomys) Nature · 2012