Topical Delivery of 4-Aminopyridine Enhances Skin Regeneration in Burn Wounds

    June 2025
    Govindraj Ellur, Meenakshi Kamaraj, John C. Elfar, Prem Kumar Govindappa, Johnson V. John
    Image of study
    TLDR 4-Aminopyridine gel speeds up burn wound healing and improves skin regeneration.
    The study explores the topical application of 4-aminopyridine (4-AP) in a laponite-gelatin gel formulation for treating burn wounds. Traditionally used for multiple sclerosis, 4-AP has been shown to accelerate burn wound closure by transforming keratinocytes and fibroblasts. The topical delivery method aims to avoid the side effects associated with systemic use. The research demonstrated that the 4-AP gel enhances wound healing by promoting re-epithelialization, hair follicle regeneration, and fibroblast to myofibroblast transformation, which aids in extracellular matrix remodeling. This approach could provide a promising alternative to existing burn treatments, potentially improving patient outcomes.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community 4.5 Months on 0,25 Finasteride only | 23M

      in Progress Pictures  39 upvotes 1 week ago
      A 23-year-old male has been using 0.25mg finasteride daily for 4.5 months to address early-stage male pattern baldness, with positive results and no significant side effects. He plans to continue with this dosage and may consider increasing it or adding minoxidil if necessary.

      community 4 months into fin, and I’m now attracted to women

      in Satire  239 upvotes 2 weeks ago
      The conversation humorously discusses the effects of finasteride on sexual orientation and hair improvement, with users joking about its potential to change attraction. It also mentions other treatments like dutasteride and minoxidil, with some users sharing their experiences and side effects.

      community 4.5 Month Update, 21m, 5mg Min + 1mg Dut

      in Progress Pictures  18 upvotes 3 weeks ago
      A 21-year-old is using 5mg Minoxidil, 1mg Dutasteride, Nizoral, and occasional microneedling for hair loss, seeing improvement on the left side of the scalp. They stopped microneedling due to scalp inflammation and are awaiting a dermatologist appointment.

    Similar Research

    5 / 1000+ results