Topical Delivery of 4-Aminopyridine Enhances Skin Regeneration in Burn Wounds

    June 2025
    Govindraj Ellur, Meenakshi Kamaraj, John C. Elfar, Prem Kumar Govindappa, Johnson V. John
    Image of study
    TLDR 4-Aminopyridine gel speeds up burn wound healing and improves skin regeneration.
    The study explores the topical application of 4-aminopyridine (4-AP) in a laponite-gelatin gel formulation for treating burn wounds. Traditionally used for multiple sclerosis, 4-AP has been shown to accelerate burn wound closure by transforming keratinocytes and fibroblasts. The topical delivery method aims to avoid the side effects associated with systemic use. The research demonstrated that the 4-AP gel enhances wound healing by promoting re-epithelialization, hair follicle regeneration, and fibroblast to myofibroblast transformation, which aids in extracellular matrix remodeling. This approach could provide a promising alternative to existing burn treatments, potentially improving patient outcomes.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community 4 months of low-dose Minoxidil

      in Progress Pictures  270 upvotes 1 week ago
      A 21-year-old male used low-dose 5% topical Minoxidil inconsistently for four months, resulting in stopped hair shedding and improved hair density, though the hairline remained unchanged. Users discussed the potential use of finasteride and other treatments, with some suggesting consulting a dermatologist for further advice.

      community 4.5 year fin/.5 year dut progress update

      in Progress Pictures  178 upvotes 3 weeks ago
      The user maintained hair with finasteride for 4.5 years and noticed some progress with dutasteride after 6 months, experiencing reduced chest and facial hair. They did not use minoxidil and reported no side effects from either treatment.

      community 4 months progress, fin/min daily

      in Is this regrowth?  194 upvotes 4 weeks ago
      The user experienced significant hair improvement after 4 months of using 1.25mg finasteride daily and 5% Minoxidil foam. They reported no side effects and no noticeable shedding phase.

    Similar Research

    5 / 1000+ results