Role of Skin Enzymes in Metabolism of Topical Drugs

    September 2024 in “ Metabolism and Target Organ Damage ”
    Nikki Lau, Khanh Phan, Yousuf Mohammed
    TLDR Skin enzymes convert topical drugs into active forms, affecting drug effectiveness and safety.
    The document discusses the significant role of skin enzymes in the metabolism of topical drugs, highlighting their ability to convert prodrug compounds into active pharmaceutical ingredients through enzymatic action. The skin acts as a barrier that metabolizes, filters, and detoxifies drugs, impacting their pharmacokinetics and minimizing side effects. Understanding skin enzyme activity is crucial for evaluating the safety and bioequivalence of topical drugs, necessitating models that assess enzyme metabolic activity in both healthy and compromised skin. The review compiles information on skin metabolizing enzymes, their roles, localization, and quantification, and discusses factors affecting enzyme metabolism in drug development. Regulatory efforts are also noted in developing protocols for evaluating transdermal product metabolism.
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