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      research Role of skin enzymes in metabolism of topical drugs

      6 citations , September 2024 in “Metabolism and Target Organ Damage”
      This review discusses the role of skin enzymes in drug metabolism and emphasizes the need for models assessing enzyme activity to evaluate the safety and bioequivalence of topical generic drugs, highlighting efforts to standardize testing protocols for transdermal products.

      research 138 Characterization of xenobiotic metabolizing enzymes of a reconstructed human epidermal model from adult hair follicles

      September 2017 in “˜The œjournal of investigative dermatology/Journal of investigative dermatology”
      In this study, the reconstructed skin epidermal model derived from hair follicles showed gene expression and enzyme functionality consistent with native human skin, suggesting its viability for studying skin metabolism and potential toxicity of dermo-cosmetic ingredients.

      research Sebocytes are the Key Regulators of Androgen Homeostasis in Human Skin

      196 citations , May 2001 in “˜The œjournal of investigative dermatology/Journal of investigative dermatology”
      This study found that SZ95 sebocytes and HaCaT keratinocytes exhibit distinct enzyme expressions and activities, implicating their different roles in androgen metabolism and homeostasis in vitro.

      research Cytochrome P450: A Target for Drug Development for Skin Diseases

      115 citations , August 2004 in “˜The œjournal of investigative dermatology/Journal of investigative dermatology”
      This review discusses the role of cytochrome P450 enzymes in skin metabolism and drug development for skin diseases, highlighting their importance and suggesting further research, but reports no new experimental findings.
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      community My Idea for a possible new hairloss treatment

       53 upvotes 6 years ago
      Exploring a potential hair loss treatment using the enzyme AKR1C2 to locally reduce DHT levels. Challenges include enzyme delivery through the skin and high production costs, with gene therapy or stem cells suggested as future alternatives.

      community Bile Acid-Mediated DHT Dysregulation Hypothesis

      in Research/Science  13 upvotes 1 year ago
      Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.

      community How many of you guys have taken accutane?

      in Chat  8 upvotes 1 year ago
      Accutane may accelerate hair loss in genetically predisposed individuals by affecting enzymes related to DHT metabolism. Some users report hair loss after taking Accutane, while others use treatments like finasteride and minoxidil to manage hair loss.
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