learn Microneedling
technique to create small wounds in skin to activate collagen production and hair growth
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5 / 28 resultslearn Peppermint
herb and oil thought to stimulate skin and hair
learn Follistatin
glycoprotein that inhibits TGF-β and promotes hair growth by antagonizing activin
learn Stemoxydine
chemical from L'Oreal that encourages hair to enter growth phase
learn Epidermal Growth Factor
Research
5 / 1000+ resultsresearch Role of skin enzymes in metabolism of topical drugs
The document discusses the significant role of skin enzymes in the metabolism of topical drugs, highlighting their ability to convert prodrug compounds into active pharmaceutical ingredients through enzymatic action. The skin acts as a barrier that metabolizes, filters, and detoxifies drugs, impacting their pharmacokinetics and minimizing side effects. Understanding skin enzyme activity is crucial for evaluating the safety and bioequivalence of topical drugs, necessitating models that assess enzyme metabolic activity in both healthy and compromised skin. The review compiles information on skin metabolizing enzymes, their roles, localization, and quantification, and discusses factors affecting enzyme metabolism in drug development. Regulatory efforts are also noted in developing protocols for evaluating transdermal product metabolism.
research Cytochrome P450: A Target for Drug Development for Skin Diseases
Modulating Cytochrome P450 activity could help develop new skin disease treatments.
research Xenobiotic-Metabolizing Enzymes in the Skin of Rat, Mouse, Pig, Guinea Pig, Man, and in Human Skin Models
Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.
research Characterization of Xenobiotic Metabolizing Enzymes of a Reconstructed Human Epidermal Model from Adult Hair Follicles
The reconstructed skin model from hair follicles functions like human skin in processing chemicals and can be used to test ingredient safety.
research Sebocytes Are the Key Regulators of Androgen Homeostasis in Human Skin
Sebocytes play a key role in controlling androgen levels in human skin.
Community Join
5 / 1000+ resultscommunity How many of you guys have taken accutane?
Accutane may accelerate hair loss in genetically predisposed individuals by affecting enzymes related to DHT metabolism. Some users report hair loss after taking Accutane, while others use treatments like finasteride and minoxidil to manage hair loss.
community DHT levels after 4 weeks of Fina and 8 weeks of Fina + 4 weeks of Duta
The user reported early stage diffuse hair thinning and increased DHT levels after 4 weeks on Finasteride and 8 weeks on Finasteride plus 4 weeks on Dutasteride, despite the medications being authentic and stored properly. They are considering increasing their Dutasteride dosage due to the lack of side effects and are unsure if the treatment is helping their hair.
community How is it possible for someone to be a non responder to ORAL minoxidil?
Some individuals do not respond to oral minoxidil for hair loss, despite it generally working by improving blood flow to hair follicles. Factors like metabolism, drug interactions, and individual variations in the drug's activation may influence its effectiveness.
community Dutasteride 1.5 years and Oral Minoxidil 1 year progress!
A user switched from finasteride to dutasteride and added oral minoxidil for hair loss but saw limited improvement. They are considering increasing doses, trying RU58841, and possibly a hair transplant, while others suggest checking for vitamin deficiencies.
community ~5 months topical minoxidil + oral finasteride results (swipe images). Slacked with minoxidil this past month, trying to wean off anyways. My last update because I’m hopping off fin and switching to RU in a few weeks (nothing to do with fin efficacy, just experimenting).
The user experienced significant hair thickening after using topical minoxidil and oral finasteride for about 5 months and is considering switching from finasteride to RU58841. Other users encourage the original poster to continue the current treatment due to the positive results.