Forum
August 2012
in “
Pharmaceutical Medicine
”
TLDR The document concludes that various medications and treatments can have significant, sometimes adverse, effects on health outcomes.
The document summarizes findings from various studies on health outcomes and medication risks. One study from the Archives of Internal Medicine involving 51,949 patients showed that higher patient satisfaction was linked to increased healthcare costs, prescription drug expenditure, inpatient use, and mortality, but decreased emergency room visits. Another study with 292 statin users found that ICD-9 codes underestimated the incidence of statin-related rhabdomyolysis. The American Geriatrics Society updated the Beers Criteria, identifying 53 potentially inappropriate medications for older adults. A secondary analysis of the CUTLASS-1 trial found no difference in extrapyramidal side effects between first- and second-generation antipsychotics. Research in the Netherlands linked SSRI use during pregnancy to preterm birth and untreated maternal depression to slower fetal growth. Canadian research associated current fluoroquinolone use with a higher risk of retinal detachment. A study in Taiwan connected herbal medicines containing aristolochic acid to urothelial cancer. Health Canada updated finasteride and dutasteride labels to include high-grade prostate cancer risk. A study suggested a link between long-acting opioids and hypogonadism in men. Another study found that vitamin E and selenium might increase prostate cancer risk. A study of 1979 men showed that short-course ADT did not increase cardiovascular mortality. Research on 2408 men suggested that statins and aspirin might affect prostate cancer detection and risk. A meta-analysis linked paracetamol and non-aspirin NSAIDs to renal cell carcinoma risk, while aspirin did not. Lastly, a meta-analysis of 4679 patients found that VEGFR TKIs increased the risk of fatal adverse events compared to controls.