Hypogonadism as a Reversible Cause of Torsades de Pointes in Men

The study identified hypogonadism as a reversible cause of Torsades de Pointes (TdP) in men. Seven men with TdP had hypogonadism, and correcting their low testosterone levels led to shortened QT intervals and no recurrence of TdP. Analysis of a pharmacovigilance database and an electronic health record cohort supported the association between hypogonadism and long QT syndrome/TdP. The findings suggested that testosterone replacement therapy could treat or prevent TdP in men with hypogonadism, and androgen deprivation therapy (ADT) could increase the risk of TdP. The study recommended investigating hypogonadism in men with TdP and considering it a risk factor.