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3 / 3 resultslearn Epidermal Growth Factor
learn Osteopontin
signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
Research
5 / 1000+ resultsresearch Role of skin enzymes in metabolism of topical drugs
The document discusses the significant role of skin enzymes in the metabolism of topical drugs, highlighting their ability to convert prodrug compounds into active pharmaceutical ingredients through enzymatic action. The skin acts as a barrier that metabolizes, filters, and detoxifies drugs, impacting their pharmacokinetics and minimizing side effects. Understanding skin enzyme activity is crucial for evaluating the safety and bioequivalence of topical drugs, necessitating models that assess enzyme metabolic activity in both healthy and compromised skin. The review compiles information on skin metabolizing enzymes, their roles, localization, and quantification, and discusses factors affecting enzyme metabolism in drug development. Regulatory efforts are also noted in developing protocols for evaluating transdermal product metabolism.
research Keratinocytes and Adipose-Derived Mesenchymal Stem Cells: The Heir and the Spare to Regenerative Cellular Therapies for Difficult-to-Heal Skin Wounds
Keratinocytes and adipose-derived stem cells can effectively heal difficult skin wounds.
research Structural and Functional Studies of L-PGDS and SMPDL3A Enzymes in Lipid Signaling Family
L-PGDS has specific binding sites for its functions and could help in drug delivery system design.
research Pharmacodynamic Evaluation: Endocrinology
The conclusion is that endocrinology significantly impacts medicine with various common medications used for treatment.
research Nitric Oxide: Physiological Functions, Delivery, and Biomedical Applications
Nitric Oxide has potential in medicine, especially for infections and heart treatments, but its short life and delivery challenges limit its use.
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5 / 56 resultscommunity Androgenetic alopecia is a skin disease: DHT-mediated skin disorders
Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.
community Is it time to quit Minoxidil? Or there's something i can do? Help
The user saw no results from Minoxidil after a year and suspects it aged their face. They started Finasteride and are considering other treatments like oral Minoxidil, microneedling, and skincare routines.
community I literally can’t find any evidence of sulfotransferase being upregulated by microneedling or retinoids like tretinoin
Microneedling and tretinoin may enhance minoxidil absorption for hair loss, but evidence on their effectiveness is limited. Iron supplements and broccoli sprouts are suggested for enzyme activation, but their impact on hair is unclear.
community Can liver problems be associated with response to the oral minoxidil?
Liver problems may reduce the effectiveness of oral minoxidil due to impaired SULT1A1 enzyme activity, which is crucial for converting minoxidil to its active form. This reduction in enzyme function can significantly decrease the drug's effectiveness in promoting hair growth.
community Minoxidil is a 5ar inhibitor according to research
Minoxidil may inhibit androgen receptors and affect hormonal pathways, potentially explaining its effectiveness in treating androgenetic alopecia (AGA). Users discuss its varying effectiveness on scalp versus facial hair and note fewer side effects with topical use compared to oral.