learn Rapamycin
mTOR regulator and immunosuppressant used more recently for anti-aging and hair regrowth
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5 / 1000+ resultsresearch Role of skin enzymes in metabolism of topical drugs
The document discusses the significant role of skin enzymes in the metabolism of topical drugs, highlighting their ability to convert prodrug compounds into active pharmaceutical ingredients through enzymatic action. The skin acts as a barrier that metabolizes, filters, and detoxifies drugs, impacting their pharmacokinetics and minimizing side effects. Understanding skin enzyme activity is crucial for evaluating the safety and bioequivalence of topical drugs, necessitating models that assess enzyme metabolic activity in both healthy and compromised skin. The review compiles information on skin metabolizing enzymes, their roles, localization, and quantification, and discusses factors affecting enzyme metabolism in drug development. Regulatory efforts are also noted in developing protocols for evaluating transdermal product metabolism.
research Original Research—Endocrinology: Comparison of the Steady-State Pharmacokinetics, Metabolism, and Variability of a Transdermal Testosterone Patch Versus a Transdermal Testosterone Gel in Hypogonadal Men
The testosterone patch and gel are both effective, but they have different absorption patterns and effects on hormone levels.
research Lipid Nanoparticles for Topical and Transdermal Delivery of Pharmaceuticals and Cosmeceuticals
Lipid nanoparticles improve drug delivery through the skin, offering stability, controlled release, and better compatibility with skin.
research Therapeutic Applications and Pharmacoeconomics of Microneedle Technology
Microneedle technology is beneficial for drug delivery and could make vaccinations cheaper and more accessible.
research Generic Development of Topical Dermatologic Products: Formulation Development, Process Development, and Testing
The document concludes that developing generic topical drugs requires ensuring they match the original in quality, composition, and structure, and often involves complex testing and regulatory steps.
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5 / 37 resultscommunity Possible natural pp405 solution
Rotenone, a natural plant extract, may promote hair growth by increasing LDH activity and blocking MPC in the scalp, but it carries risks due to its toxicity. The suggested formulation includes Barbasco extract, DMSO, propylene glycol or PEG-400, ethanol, and a carrier oil.
community New and Interesting HairLoss Studies/Papers/Reviews
Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.
community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.
Most hair loss treatments are ineffective; only finasteride, dutasteride, and minoxidil show effectiveness.
community How do I not kill my partners cat while using minoxidil ?
Minoxidil is toxic to cats, so users should wash hands after application and ensure it dries before pets are near. Some switch to oral minoxidil to avoid risks, while others use topical forms cautiously.
community PP405 Identity Research
PP405 is a potential hair loss treatment that inhibits mitochondrial pyruvate carriers, increasing lactate dehydrogenase activity and stimulating hair follicle stem cells. In a phase 1 trial, 31% of participants showed over 20% hair density increase with PP405 treatment.