learn Tretinoin
the gold standard retinoid in dermatology that's also helpful for hair regrowth alongside Minoxidil
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5 / 19 resultslearn Sulforaphane
compound from cruciferous vegetables has some mild effects on DHT
learn Overview
learn Melatonin
hormone commonly taken for sleep aid has some topical benefits for hair
learn Azelaic Acid
acid used for antimicrobial, anti-inflammatory and anti-androgenic properties
Research
5 / 1000+ results
research Xenobiotic-Metabolizing Enzymes in the Skin of Rat, Mouse, Pig, Guinea Pig, Man, and in Human Skin Models
Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.
research Transdermal Permeation of Drugs in Various Animal Species
Pig skin is a good substitute for human skin to measure drug absorption, but differences in skin structure and enzymes across species must be considered.
research Cytochrome P450: A Target for Drug Development for Skin Diseases
Modulating Cytochrome P450 activity could help develop new skin disease treatments.
research Mice Lacking the Epidermal Retinol Dehydrogenases SDR16C5 and SDR16C6 Display Accelerated Hair Growth and Enlarged Meibomian Glands
Mice without certain skin enzymes have faster hair growth and bigger eye glands.
research Cutaneous Androgen Metabolism: Basic Research And Clinical Perspectives
Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.
Community Join
5 / 1000+ resultscommunity Anyone here get results from topical melatonin?
A user has been using finasteride and minoxidil for hair loss but is experiencing increased shedding and is considering using topical melatonin with a product called Rizn. Another user is skeptical about the effectiveness of topical melatonin due to issues with the research and lack of replication of results, while a third user expresses interest in the outcome of using Rizn after not seeing results from topical finasteride and minoxidil.
community So does oral minoxidil age your skin or not
Oral minoxidil may cause dry skin and dark eye bags but doesn't significantly age the skin. Topical minoxidil is toxic to cats, and some users prefer finasteride.
community New hack? Tretinoin enhances minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes
The conversation discusses how Tretinoin may improve the effectiveness of Minoxidil for treating hair loss by increasing the activity of certain enzymes in hair follicles. One user comments that this information is not new.
community Did you notice any other positive effect while on finasteride/dutasteride?
Finasteride and dutasteride can stop hair loss and improve skin, with some users experiencing increased libido and harder erections. However, some report side effects like softer erections and brain fog.
community Oral Minoxidil - Week by week progress thread.
The user shared their experience with liquid Minoxidil, which initially worked well but caused severe skin irritation, leading them to stop. They are now trying oral Minoxidil and plan to document their progress weekly.