Silk Fibroin Hydrogel with Recombinant Silk Fibroin/NT3 Protein Enhances Wound Healing by Promoting Type III Collagen Synthesis and Hair Follicle Regeneration in Skin Injury

    June 2025 in “ Materials Today Bio ”
    Yingying Yan, Mingxuan Li, Longyu Guo … Yan Liu
    Studysummary In this study, a silk fibroin hydrogel containing recombinant NT3 was found to promote scar-less wound healing in a mouse skin injury model by enhancing type III collagen expression and inducing hair follicle formation.
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    Research cited in this study 5

    1. Type III Collagen Regulates Matrix Architecture and Mechanosensing During Wound Healing Journal of Investigative Dermatology · 2024
    2. Nerve Growth Factor and Burn Wound Healing: Update of Molecular Interactions With Skin Cells Burns · 2023
    3. Advanced Nanocarrier- and Microneedle-Based Transdermal Drug Delivery Strategies for Skin Diseases Treatment Theranostics · 2022
    4. Activating an Adaptive Immune Response from a Hydrogel Scaffold Imparts Regenerative Wound Healing Nature Materials · 2020
    5. Wound Healing and Skin Regeneration Cold Spring Harbor Perspectives in Medicine · 2015