Hair Follicle Transplantation Promotes Skin Ulcer Healing in a Mouse Model of Experimental Diabetes

This study demonstrates that hair follicle (HF) transplantation significantly accelerates wound healing in diabetic mice by promoting re-epithelialization, wound contraction, angiogenesis, and collagen deposition while reducing inflammation. Conducted on 36 male C57BL/6 mice, the research found that HF transplantation improved healing rates in both normoglycemic and hyperglycemic conditions, with diabetic wounds healing up to 98.46% by day 10 post-transplantation. The transplantation process enhances cellular proliferation, increases microvessel density, and reduces inflammatory cytokines, suggesting an immunomodulatory role of mesenchymal stem cells within HFs. Despite the challenges of hyperglycemia, HF transplantation remains a promising therapeutic strategy for diabetic wounds, although further research is needed to explore long-term effects and clinical feasibility.