Hair Follicle Transplantation Promotes Skin Ulcer Healing in a Mouse Model of Experimental Diabetes

    August 2025 in “ Scientific Reports ”
    Qian Hu, Xue Peng, Yuqian Yang, Zhongshan Liu
    Studysummary This study found that hair follicle transplantation improved wound healing in diabetic mice by promoting tissue regeneration and reducing inflammation, with follicles from normoglycemic conditions proving more effective than those from hyperglycemic environments.
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    Research cited in this study 21

    1. Diabetes Mellitus Inhibits Hair Follicle Regeneration by Inducing Macrophage Reprogramming-Mediated Pyroptosis Journal of Inflammation Research · 2024
    2. Hair Follicle Punch Grafts in Hard-To-Heal Wounds: A Monocenter Study and Patient Survey Health Science Reports · 2024
    3. Autophagy Induces Hair Follicle Stem Cell Activation and Hair Follicle Regeneration by Regulating Glycolysis 2024
    4. Local and Systemic Mechanisms That Control the Hair Follicle Stem Cell Niche Nature Reviews Molecular Cell Biology · 2023
    5. Umbilical Cord Mesenchymal Stem Cell-Derived Apoptotic Extracellular Vesicles Ameliorate Cutaneous Wound Healing in Type 2 Diabetic Mice via Macrophage Pyroptosis Inhibition Stem cell research & therapy · 2023
    6. Hair Follicle Mesenchymal Stem Cell Exosomal LncRNA H19 Inhibited NLRP3 Pyroptosis to Promote Diabetic Mouse Skin Wound Healing Aging · 2023
    7. Anagen Hair Follicles Transplanted Into Mature Human Scars Remodel Fibrotic Tissue npj regenerative medicine · 2023
    8. Wnt/β-Catenin Signaling Activator Restores Hair Regeneration Suppressed by Diabetes Mellitus BMB Reports · 2022
    9. Type 2 Diabetes Mellitus Inhibits Skin Renewal Through Inhibiting WNT-Dependent Lgr5+ Hair Follicle Stem Cell Activation in C57BL/6 Mice Journal of diabetes research · 2022
    10. Extracellular Vesicles from Hair Follicle-Derived Mesenchymal Stromal Cells: Isolation, Characterization, and Therapeutic Potential for Chronic Wound Healing Stem cell research & therapy · 2022
    11. Hair Transplantation: Basic Overview Journal of The American Academy of Dermatology · 2021
    12. Theoretical Basis and Clinical Practice for FUE Megasession Hair Transplantation in the Treatment of Large Area Androgenic Alopecia Journal of Cosmetic Dermatology · 2020
    13. Overexpression of Alkaline Phosphatase Improves the Hair-Inductive Capacity of Cultured Human Dermal Papilla Spheres Journal of Dermatological Science · 2019
    14. Regeneration of Dermis: Scarring and Cells Involved Cells · 2019
    15. Hair Biology Facial Plastic Surgery Clinics of North America · 2018
    16. Stem Cells from Human Hair Follicles: First Mechanical Isolation for Immediate Autologous Clinical Use in Androgenetic Alopecia and Hair Loss Stem cell investigation · 2017
    17. Hair-Follicle Transplant Into Chronic Ulcers: A New Graft Concept Actas dermo-sifiliográficas/Actas dermo-sifiliográficas · 2017
    18. Hair Follicle Characteristics as Early Marker of Type 2 Diabetes Medical Hypotheses · 2016
    19. Skin Grafting for the Treatment of Chronic Leg Ulcers: A Systematic Review in Evidence-Based Medicine International Wound Journal · 2016
    20. Activated Hair Follicle Stem Cells and Wnt/β-Catenin Signaling Involved in Pathogenesis of Sebaceous Neoplasms International Journal of Medical Sciences · 2014
    21. A Pilot Clinical Study of Hair Grafting in Chronic Leg Ulcers Wound Repair and Regeneration · 2012

    Related research 2

    1. Promoting Effect of Hair Follicle Stem Cells in the Wound Healing of Skin Chin J Cell Stem Cell (Electronic Edition) · 2017
    2. From Surgery to Pharmacology to Gene Therapy: The Evolution of Hair Restoration Techniques Annals of Plastic Surgery · 2010