Wnt/β-Catenin Signaling Activator Restores Hair Regeneration Suppressed by Diabetes Mellitus

November 2022 in “ BMB Reports ”

Yeong Chan Ryu, You-Rin Kim, Jiyeon Park, Sehee Choi, Geon-Uk Kim, Eunhwan Kim, Yumi Hwang, Heejene Kim, Soon Sun Bak, Jin Eun Lee, Young Kwan Sung, Gyoonhee Han, Soung-Hoon Lee, Kang-Yell Choi

Wnt/β-catenin signaling diabetes mellitus hair regeneration hair follicle neogenesis KY19382 hair follicle cells alopecia Wnt signaling hair regrowth hair loss diabetes-induced hair loss

TLDR Wnt/β-catenin activators can help regrow hair lost due to diabetes.

This study investigates the impact of diabetes on hair regeneration and the potential of a Wnt/β-catenin signaling activator, KY19382, to restore hair growth in diabetic conditions. Diabetic mice, induced by high-fat diet (HFD) and STZ administration, exhibited delayed hair cycle progression and reduced hair follicle neogenesis due to diminished Wnt/β-catenin signaling. Application of KY19382, but not minoxidil, improved anagen induction and restored hair regrowth capabilities in diabetic mice by enhancing Wnt/β-catenin signaling and cell proliferation. Additionally, KY19382 ameliorated the development of neogenic follicles and improved hair follicle elongation in a high glucose environment, suggesting its potential as a therapeutic agent for hair regeneration in diabetic conditions.

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