Hair-Follicle Transplant Into Chronic Ulcers: A New Graft Concept

June 2017 in “ Actas dermo-sifiliográficas/Actas dermo-sifiliográficas ”

M.L. Martínez Martínez, Eduardo Escario Travesedo, Francisco Jiménez Acosta

hair follicle transplant chronic venous leg ulcers compression debridement skin grafts punch-type grafts wound healing

Studysummary This study reported that using hair follicles from the scalp in punch-type grafts improved healing in chronic venous ulcers compared to traditional hairless punch grafts. Our plain-language summary of this paper — not a Tressless recommendation.

Chronic venous leg ulcers often resist traditional treatments like compression, debridement, and dressings, necessitating new healing approaches. While various skin grafts are commonly used, recent studies highlighted the hair follicle's significant role in wound healing. Scalp hair follicles transplanted into chronic ulcers via punch-type grafts showed better healing results compared to traditional hairless punch grafts, suggesting a promising new treatment for stubborn chronic venous ulcers.

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Research cited in this study

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research Multifaceted Role of Hair Follicle Dermal Cells in Bioengineered Skins

33 citations , September 2016 in “British journal of dermatology/British journal of dermatology, Supplement”

This study found that human hair follicle dermal cells, specifically dermal sheath cells, can serve as an alternative and potentially superior cell source for constructing the dermal component of bioengineered skin in both in vitro and in vivo settings.

research Wound Healing and Skin Regeneration

359 citations , January 2015 in “Cold Spring Harbor Perspectives in Medicine”

This article reviews the role of skin appendages in wound healing and appendage regeneration, discussing cellular and molecular mechanisms but reports no new experimental findings.

research Advances in Skin Grafting and Treatment of Cutaneous Wounds

518 citations , November 2014 in “Science”

This review discusses current and experimental treatments for cutaneous wounds, emphasizing cell-based therapies and skin transplantation, but reports no new clinical results.

Dermal Papilla Cells Improve Wound Healing and Generate Hair Bud-Like Structures in Grafted Skin Substitutes Using Hair Follicle Stem Cells

research Dermal Papilla Cells Improve Wound Healing and Generate Hair Bud-Like Structures in Grafted Skin Substitutes Using Hair Follicle Stem Cells

68 citations , August 2014 in “Stem Cells Translational Medicine”

This study found that composite skin constructs containing dermal papilla cells promoted better skin healing and hair regeneration in nude mice, highlighting their role in tissue-engineered skin for severe injuries.

research Reflections on How Wound Healing-Promoting Effects of the Hair Follicle Can Be Translated into Clinical Practice

43 citations , July 2014 in “Experimental Dermatology”

This review explores the relationship between hair follicles and wound healing, emphasizing the importance of translating scientific findings into practical therapies for chronic wounds, but it reports no new experimental results.

research Epigenetic Control of Skin and Hair Regeneration After Wounding

36 citations , July 2014 in “Experimental Dermatology”

This narrative piece considers how epigenetic factors may influence the processes of skin wound healing, including hair follicle formation, but it presents no new experimental results.

research A Pilot Clinical Study of Hair Grafting in Chronic Leg Ulcers

63 citations , October 2012 in “Wound Repair and Regeneration”

This study found that transplanting autologous scalp follicular grafts into chronic leg ulcers led to a greater reduction in ulcer size compared to non-grafted areas, suggesting a promising therapeutic alternative.

research Review of Hair Follicle Dermal Cells

321 citations , December 2009 in “Journal of Dermatological Science”

This review discusses the role of dermal cells in hair follicle regeneration and morphogenesis and highlights their potential therapeutic implications, but it reports no new empirical findings.

research Exploring the Role of Stem Cells in Cutaneous Wound Healing

222 citations , August 2009 in “Experimental Dermatology”

This review discusses the role of stem cells in cutaneous wound healing and reports no clinical results; the authors highlight the need for better understanding of underlying mechanisms for future therapies.

research An Extended Epidermal Response Heals Cutaneous Wounds in the Absence of a Hair Follicle Stem Cell Contribution

170 citations , November 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that in the absence of hair follicles, cutaneous wounds in mice showed delayed reepithelialization but eventually achieved normal wound closure after expanding the activated epidermis region.

research Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis

1279 citations , November 2005 in “Nature Medicine”

Reepithelialization of a Full-Thickness Burn from Stem Cells of Hair Follicles Micrografted into a Tissue-Engineered Dermal Template (Integra)

research Reepithelialization of a Full-Thickness Burn from Stem Cells of Hair Follicles Micrografted into a Tissue-Engineered Dermal Template (Integra)

87 citations , February 2004 in “Plastic and Reconstructive Surgery”

In this study, researchers achieved complete reepithelialization and hair growth on a burn-injured scalp using a tissue-engineered dermal template with early micrograft hair follicle implantation.

research Trans-Species Hair Growth Induction by Human Hair Follicle Dermal Papillae

66 citations , August 2001 in “Experimental Dermatology”

This study demonstrated that intact adult human dermal papillae can induce hair growth when implanted into mouse hair follicles, highlighting their potential for advancing hair follicle biology and therapeutic approaches.