Hair-Follicle Transplant Into Chronic Ulcers: A New Graft Concept

June 2017 in “ Actas dermo-sifiliográficas/Actas dermo-sifiliográficas ”

M.L. Martínez Martínez, Eduardo Escario Travesedo, Francisco Jiménez Acosta

hair follicle transplant chronic venous leg ulcers compression debridement skin grafts punch-type grafts wound healing

TLDR Transplanting hair follicles into chronic ulcers helps them heal better.

Chronic venous leg ulcers often resist traditional treatments like compression, debridement, and dressings, necessitating new healing approaches. While various skin grafts are commonly used, recent studies highlighted the hair follicle's significant role in wound healing. Scalp hair follicles transplanted into chronic ulcers via punch-type grafts showed better healing results compared to traditional hairless punch grafts, suggesting a promising new treatment for stubborn chronic venous ulcers.

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Research cited in this study

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research Multifaceted Role of Hair Follicle Dermal Cells in Bioengineered Skins

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research Dermal Papilla Cells Improve Wound Healing and Generate Hair Bud-Like Structures in Grafted Skin Substitutes Using Hair Follicle Stem Cells

68 citations, August 2014 in “Stem Cells Translational Medicine”

Dermal papilla cells help wounds heal better and can potentially grow new hair.

research Reflections on How Wound Healing-Promoting Effects of the Hair Follicle Can Be Translated into Clinical Practice

43 citations, July 2014 in “Experimental Dermatology”

Hair follicles can help wounds heal faster and this knowledge could be used to treat chronic skin ulcers, with a potential use of a special stem cell hydrogel to enhance healing.

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36 citations, July 2014 in “Experimental Dermatology”

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321 citations, December 2009 in “Journal of Dermatological Science”

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research Exploring the Role of Stem Cells in Cutaneous Wound Healing

222 citations, August 2009 in “Experimental Dermatology”

Stem cells are crucial for wound healing and understanding their role could lead to new treatments, but more research is needed to answer unresolved questions.

research An Extended Epidermal Response Heals Cutaneous Wounds in the Absence of a Hair Follicle Stem Cell Contribution

170 citations, November 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Skin can heal wounds without hair follicle stem cells, but it takes a bit longer.

Reepithelialization of a Full-Thickness Burn from Stem Cells of Hair Follicles Micrografted into a Tissue-Engineered Dermal Template (Integra)

research Reepithelialization of a Full-Thickness Burn from Stem Cells of Hair Follicles Micrografted into a Tissue-Engineered Dermal Template (Integra)

87 citations, February 2004 in “Plastic and Reconstructive Surgery”

Hair follicle stem cells helped heal a severe scalp burn without needing traditional skin grafts.

research Trans-Species Hair Growth Induction by Human Hair Follicle Dermal Papillae

66 citations, August 2001 in “Experimental Dermatology”

Human hair follicle cells can grow hair when put into mouse skin if they stay in contact with mouse cells.

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