Hair-Follicle Transplant Into Chronic Ulcers: A New Graft Concept

July 2017 in “ Actas dermo-sifiliográficas/Actas dermo-sifiliográficas ”

M.L. Martínez Martínez, Eduardo Escario Travesedo, Francisco Jiménez Acosta

hair follicle transplant chronic venous leg ulcers compression debridement skin grafts punch-type grafts wound healing

TLDR Transplanting hair follicles into chronic ulcers helps them heal better.

Chronic venous leg ulcers often resist traditional treatments like compression, debridement, and dressings, necessitating new healing approaches. While various skin grafts are commonly used, recent studies highlighted the hair follicle's significant role in wound healing. Scalp hair follicles transplanted into chronic ulcers via punch-type grafts showed better healing results compared to traditional hairless punch grafts, suggesting a promising new treatment for stubborn chronic venous ulcers.

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research Multifaceted Role of Hair Follicle Dermal Cells in Bioengineered Skins

33 citations , March 2017 in “British journal of dermatology/British journal of dermatology, Supplement”

Human hair follicle dermal cells can effectively replace other cells in engineered skin.

research Wound Healing and Skin Regeneration

359 citations , January 2015 in “Cold Spring Harbor Perspectives in Medicine”

Hair growth phase and certain genes can speed up wound healing, while an inflammatory mediator can slow down new hair growth after a wound. Understanding these factors can improve tissue regeneration during wound healing.

research Advances in Skin Grafting and Treatment of Cutaneous Wounds

518 citations , November 2014 in “Science”

Skin grafting and wound treatment have improved, but we need more research to better understand wound healing and create more effective treatments.

research Epigenetic Control of Skin and Hair Regeneration After Wounding

36 citations , November 2014 in “Experimental Dermatology”

Skin and hair can regenerate after injury due to changes in gene activity, with potential links to how cancer spreads. Future research should focus on how new hair follicles form and the processes that trigger their creation.

research Reflections on How Wound Healing-Promoting Effects of the Hair Follicle Can Be Translated into Clinical Practice

43 citations , November 2014 in “Experimental Dermatology”

Hair follicles can help wounds heal faster and this knowledge could be used to treat chronic skin ulcers, with a potential use of a special stem cell hydrogel to enhance healing.

research Dermal Papilla Cells Improve Wound Healing and Generate Hair Bud-Like Structures in Grafted Skin Substitutes Using Hair Follicle Stem Cells

68 citations , August 2014 in “Stem Cells Translational Medicine”

Dermal papilla cells help wounds heal better and can potentially grow new hair.

research Review of Hair Follicle Dermal Cells

321 citations , January 2010 in “Journal of Dermatological Science”

Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.

research Exploring the Role of Stem Cells in Cutaneous Wound Healing

222 citations , November 2009 in “Experimental Dermatology”

Stem cells are crucial for wound healing and understanding their role could lead to new treatments, but more research is needed to answer unresolved questions.

research An Extended Epidermal Response Heals Cutaneous Wounds in the Absence of a Hair Follicle Stem Cell Contribution

170 citations , May 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

Skin can heal wounds without hair follicle stem cells, but it takes a bit longer.

research Reepithelialization of a Full-Thickness Burn from Stem Cells of Hair Follicles Micrografted into a Tissue-Engineered Dermal Template (Integra)

87 citations , March 2004 in “Plastic and Reconstructive Surgery”

Hair follicle stem cells helped heal a severe scalp burn without needing traditional skin grafts.

research Trans-Species Hair Growth Induction by Human Hair Follicle Dermal Papillae

66 citations , August 2001 in “Experimental Dermatology”

Human hair follicle cells can grow hair when put into mouse skin if they stay in contact with mouse cells.