Platelet-Rich Plasma as an Adjuvant in Full-Thickness Skin Wound Healing in Rabbits
April 2025
in “
Assiut Veterinary Medical Journal/Maǧallaẗ Asyūṭ al-ṭibiyyaẗ al-baytariyyaẗ
”
New to Platelet-Rich Plasma? There is a guide in the encyclopedia. Read the guide → Studysummary In this study, PRP significantly accelerated early wound healing in rabbits, with faster closure and improved tissue characteristics compared to controls, although both groups achieved near-complete healing by four weeks.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
This study investigated the effects of platelet-rich plasma (PRP) on full-thickness skin wound healing in 12 rabbits. Each rabbit had two wounds, with one treated with PRP and the other serving as a control. Results showed that PRP significantly accelerated wound healing, with 58.17% closure by week 2 compared to 30.17% in controls. By week 4, both groups achieved near-complete closure, but PRP-treated wounds showed faster initial healing. Histopathological analysis revealed complete re-epithelialization and reduced inflammation in the PRP group at 2 weeks, and increased epithelial coverage with hair follicle proliferation at 4 weeks, unlike the control group. The study concludes that PRP significantly enhances wound healing, especially in the early stages, indicating its potential in improving skin wound repair.
