Novel Biodegradable Polymeric Microparticles Facilitate Scarless Wound Healing by Promoting Re-Epithelialization and Inhibiting Fibrosis

The study investigated biodegradable polymeric microparticles (MPs) made from fibroin/gelatin and spidroin for their ability to promote scarless wound healing in mice. Both types of MPs enhanced re-epithelialization and reduced scar formation, demonstrating their potential in facilitating scarless healing. Fibroin/gelatin MPs induced a transient inflammatory response and increased proinflammatory myeloid cell infiltration, while both MPs downregulated profibrotic growth factors. The study highlighted the anti-fibrotic properties of these MPs, with fibroin/gelatin MPs uniquely modulating immune responses, suggesting their potential for improving wound healing outcomes.