CD80 on Skin Stem Cells Promotes Local Expansion of Regulatory T Cells Upon Injury to Orchestrate Repair Within an Inflammatory Environment

    April 2024 in “ Immunity ”
    Jingyun Luan, Cynthia Truong, Aleksandra Vuchkovska … Yuxuan Miao
    Studysummary In this study, researchers found that hair follicle stem cells activate an immune-modulatory program during wound healing, promoting Treg cell expansion and aiding skin repair, while deleting certain immune components impaired healing and increased inflammation in a mouse model.
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    Research cited in this study 5

    1. Building and Maintaining the Skin Cold Spring Harbor Perspectives in Biology · 2021
    2. Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2017
    3. Defining Stem Cell Dynamics and Migration During Wound Healing in Mouse Skin Epidermis Nature Communications · 2017
    4. Identification of Stem Cell Populations in Sweat Glands and Ducts Reveals Roles in Homeostasis and Wound Repair Cell · 2012
    5. Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis Cell · 2000