Mimicking Fat Grafting of Fibrotic Scars Using 3D-Organotypic Skin Cultures

    July 2023 in “ Experimental Dermatology ”
    Rajiv S. Raktoe, Anastasia K. A. L. Kwee, Marion Rietveld … Abdoelwaheb El Ghalbzouri
    Studysummary This study found that incorporating human adipose subcutaneous tissue in 3D organotypic skin cultures mimicking hypertrophic scar conditions improved epidermal homeostasis, formed a basement membrane similar to native skin, and reduced myofibroblast presence, indicating an anti-fibrotic effect.
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    Research cited in this study 9

    1. Recreation of a Hair Follicle Regenerative Microenvironment: Successes and Pitfalls Bioengineering & translational medicine · 2021
    2. Adipokines in the Skin and Dermatological Diseases International journal of molecular sciences · 2020
    3. Reconstructed Human Skin Shows Epidermal Invagination Towards Integrated Neopapillae Indicating Early Hair Follicle Formation In Vitro Journal of Tissue Engineering and Regenerative Medicine · 2020
    4. Tissue Engineering of Human Hair Follicles Using a Biomimetic Developmental Approach Nature Communications · 2018
    5. Methods for the Isolation and 3D Culture of Dermal Papilla Cells from Human Hair Follicles Experimental Dermatology · 2017
    6. The Hair Follicle: An Underutilized Source of Cells and Materials for Regenerative Medicine ACS biomaterials science & engineering · 2017
    7. Stem Cells in Skin Regeneration, Wound Healing, and Their Clinical Applications International journal of molecular sciences · 2015
    8. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    9. SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells Cell stem cell · 2009